与先前使用氟烷相关的氟烷后黄疸
Post-halothane jaundice in relation to previous administration of halothane.
作者信息
Mushin W W, Rosen M, Jones E V
出版信息
Br Med J. 1971 Jul 3;3(5765):18-22. doi: 10.1136/bmj.3.5765.18.
The time interval since previous anaesthesia was compared in a surgical population in South Wales and in patients who developed jaundice after halothane. There was a significant difference in the pattern of time interval since previous general anaesthetics in the surgical population and in those patients who developed jaundice after halothane. In the group who developed jaundice there was an "excess" of patients who had had a previous halothane anaesthetic within four weeks. Halothane should if possible be avoided in patients who have had it before, particularly if this was within the previous four weeks. In the case of repeat halothane anaesthetics within four weeks, the risk seems to lie between 1 in 6,000 and 1 in 22,000.
对南威尔士手术人群以及氟烷麻醉后出现黄疸的患者，比较了距上次麻醉的时间间隔。手术人群与氟烷麻醉后出现黄疸的患者相比，距上次全身麻醉的时间间隔模式存在显著差异。在出现黄疸的患者组中，有“过多”患者在四周内曾接受过氟烷麻醉。以前使用过氟烷的患者，尤其是在过去四周内使用过的患者，应尽可能避免再次使用氟烷。对于四周内重复使用氟烷麻醉的情况，风险似乎在六千分之一至两万两千分之一之间。
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