反复接触氟烷后出现黄疸：对药品安全委员会报告的进一步分析
Jaundice after repeated exposure to halothane: a further analysis of reports to the Committee on Safety of Medicines.
作者信息
Inman W H, Mushin W W
出版信息
Br Med J. 1978 Nov 25;2(6150):1455-6. doi: 10.1136/bmj.2.6150.1455.
Abstract
Aanalysis of data derived from 170 reports of jaundice developing after anaesthesia with halothane received after January 1974 confirmed the relations between multiple exposure to halothane and jaundice and between the number of exposures and the rapidity with which jaundice develops after exposure. When these reports were combined with 130 received earlier complete anaesthetic histories were available for 251 patients, 205 (82%) of whom had been exposed to halothane more than once; of these patients, 154 (75%) had been exposed more than once within 28 days. Altogether 139 (46%) of the 300 patients died.
摘要
对1974年1月以后收到的170例氟烷麻醉后发生黄疸报告中的数据进行分析，证实了多次接触氟烷与黄疸之间的关系，以及接触次数与接触后黄疸发生速度之间的关系。当将这些报告与早期收到的130例报告相结合时，可获得251例患者的完整麻醉史，其中205例（82%）曾多次接触氟烷；在这些患者中，154例（75%）在28天内多次接触。300例患者中共有139例（46%）死亡。
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