Johnstone I B, Lotz F
Can Vet J. 1979 Aug;20(8):211-5.
An inherited platelet function defect occurring in a family of basset hounds has been described. The trait is transmitted as an autosomal characteristic and appears to be expressed clinically only in the homozygous state. The characteristics of this platelet defect include:1) marked bleeding tendencies and prolonged skin bleeding times in either male or female dogs.2) normal blood coagulation mechanism.3) adequate numbers of circulating platelets which appear morphologically normal by light microscopy.4) normal whole blood clot retraction.5) deficient in vivo platelet consumption and in vitro platelet retention in glass bead columns.6) defective ADP-induced platelet aggregation in homozygotes, apparently normal ADP response in heterozygotes, and defective collagen-induced platelet aggregation in both.
已描述了在一组巴吉度猎犬家族中出现的一种遗传性血小板功能缺陷。该性状作为常染色体特征进行传递，并且似乎仅在纯合状态下才在临床上表现出来。这种血小板缺陷的特征包括：1）雄性或雌性犬均有明显的出血倾向和延长的皮肤出血时间。2）正常的血液凝固机制。3）循环血小板数量充足，通过光学显微镜观察形态正常。4）全血凝块回缩正常。5）体内血小板消耗不足以及在玻璃珠柱中体外血小板滞留不足。6）纯合子中ADP诱导的血小板聚集缺陷，杂合子中ADP反应明显正常，两者中胶原蛋白诱导的血小板聚集均有缺陷。
