Boudreaux M K, Crager C, Dillon A R, Stanz K, Toivio-Kinnucan M
Department of Pathobiology, Auburn University, AL 36849-5519.
J Vet Intern Med. 1994 Mar-Apr;8(2):93-8. doi: 10.1111/j.1939-1676.1994.tb03204.x.
A recently identified intrinsic platelet function defect in 2 Spitz dogs is described. Both affected dogs had a history of chronic intermittent bleeding primarily from the nasal, oral, and gastrointestinal mucosa. Platelet aggregation in response to adenosine diphosphate (ADP), collagen, and platelet activating factor (PAF) was absent; however, platelet shape change did occur. Platelets aggregated in response to gamma thrombin, although a delayed onset and a reduced velocity of aggregation were present. Platelet 14C-serotonin release was diminished in response to collagen and PAF. Glycoprotein IIIa was detected on the surface of platelets by flow cytometry. Platelets were morphologically normal under light and electron microscopy. Two male Spitz dogs, related to one of the affected dogs, did not have a bleeding diathesis. Collagen-induced platelet aggregation, however, was diminished in these 2 dogs. This platelet defect most closely resembles the defect described in Basset hounds.
本文描述了最近在两只斯皮茨犬中发现的一种内在血小板功能缺陷。两只患病犬都有慢性间歇性出血的病史，主要出血部位为鼻、口和胃肠道黏膜。对二磷酸腺苷（ADP）、胶原蛋白和血小板活化因子（PAF）的血小板聚集反应缺失；然而，血小板形状改变确实发生。血小板对γ凝血酶有聚集反应，尽管存在延迟发作和聚集速度降低的情况。胶原蛋白和PAF刺激下血小板14C-血清素释放减少。通过流式细胞术检测到血小板表面存在糖蛋白IIIa。在光学显微镜和电子显微镜下，血小板形态正常。与其中一只患病犬相关的两只雄性斯皮茨犬没有出血素质。然而，这两只犬中胶原蛋白诱导的血小板聚集减少。这种血小板缺陷与巴吉度猎犬中描述的缺陷最为相似。
