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Activation of the O-glucuronide of the carcinogen N-hydroxy-N-2-fluorenylacetamide by enzymatic deacetylation in vitro: formation of fluorenylamine-tRNA adducts.

作者信息

Cardona R A, King C M

出版信息

Biochem Pharmacol. 1976 May 1;25(9):1051-6. doi: 10.1016/0006-2952(76)90495-0.

DOI:10.1016/0006-2952(76)90495-0
PMID:5097
Abstract
摘要

相似文献

1
Activation of the O-glucuronide of the carcinogen N-hydroxy-N-2-fluorenylacetamide by enzymatic deacetylation in vitro: formation of fluorenylamine-tRNA adducts.致癌物N-羟基-N-2-芴基乙酰胺的O-葡糖醛酸在体外经酶促脱乙酰作用激活：芴基胺-tRNA加合物的形成。
Biochem Pharmacol. 1976 May 1;25(9):1051-6. doi: 10.1016/0006-2952(76)90495-0.
2
Activation of carcinogenic arylhydroxamic acids by human tissues.人体组织对致癌芳基异羟肟酸的激活作用。
J Natl Cancer Inst. 1975 Aug;55(2):285-7.
3
Glucuronide formation in the metabolism of N-substituted aryl compounds.N-取代芳基化合物代谢中的葡萄糖醛酸苷形成。
Natl Cancer Inst Monogr. 1981 Dec(58):109-11.
4
O-sulfonation of N-hydroxy-2-fluorenylacetamide and 7-hydroxy-N-2-fluorenylacetamide in fetal and placental tissues of humans and guinea pigs.人及豚鼠胎儿和胎盘组织中N-羟基-2-芴基乙酰胺和7-羟基-N-2-芴基乙酰胺的O-磺化作用
Drug Metab Dispos. 1977 May-Jun;5(3):288-94.
5
Absorption and protein binding of N-2-fluorenylacetamide and its metabolites in the bladder of rabbit.
J Natl Cancer Inst. 1977 Feb;58(2):281-5. doi: 10.1093/jnci/58.2.281.
6
Species difference in liver microsomal and cytosolic enzymes involved in mutagenic activation of N-hydroxy-N-2-fluorenylacetamide.参与N-羟基-N-2-芴基乙酰胺诱变激活的肝脏微粒体和胞质酶的物种差异。
J Natl Cancer Inst. 1981 Sep;67(3):549-55.
7
Reduction of N-hydroxy-2-acetylaminofluorene by liver microsomes.肝脏微粒体对N-羟基-2-乙酰氨基芴的还原作用。
Biochem Pharmacol. 1980 Aug 15;29(16):2183-8. doi: 10.1016/0006-2952(80)90196-3.
8
Electrophilic N-acetoxyaminoarenes derived from carcinogenic N-hydroxy-N-acetylaminoarenes by enzymatic deacetylation and transacetylation in liver.亲电N-乙酰氧基氨基芳烃是由致癌性N-羟基-N-乙酰氨基芳烃在肝脏中通过酶促脱乙酰化和转乙酰化作用衍生而来的。
Biochim Biophys Acta. 1972 Dec 29;286(2):272-98. doi: 10.1016/0304-4165(72)90265-6.
9
Effect of bovine serum albumin on the extent of ortho rearrangement of N-(sulfooxy)-2-fluorenylacetamide and of enzymatically activated N-hydroxy-2-fluorenylacetamide and on the binding of reactive esters to nucleic acids.牛血清白蛋白对N-（磺氧基）-2-芴基乙酰胺和酶促活化的N-羟基-2-芴基乙酰胺邻位重排程度以及活性酯与核酸结合的影响。
Chem Res Toxicol. 1992 Mar-Apr;5(2):274-9. doi: 10.1021/tx00026a020.
10
Mechanisms of the inhibitory action of p-hydroxyacetanilide on carcinogenesis by N-2-fluorenylacetamide or N-hydroxy-N-2-fluorenylacetamide.对羟基乙酰苯胺对N-2-芴基乙酰胺或N-羟基-N-2-芴基乙酰胺致癌作用的抑制机制。
J Natl Cancer Inst. 1976 Apr;56(4):763-8. doi: 10.1093/jnci/56.4.763.

引用本文的文献

1
Purification and characterization of guinea-pig liver microsomal deacetylase involved in the deacetylation of the O-glucoside of N-hydroxyacetanilide.豚鼠肝脏微粒体中参与N-羟基乙酰苯胺O-葡萄糖苷脱乙酰化的脱乙酰酶的纯化与特性研究
Biochem J. 1997 Jul 1;325 ( Pt 1)(Pt 1):155-61. doi: 10.1042/bj3250155.
2
Pharmacokinetics and molecular detoxication.药代动力学与分子解毒作用。
Environ Health Perspect. 1996 Mar;104 Suppl 1(Suppl 1):23-40. doi: 10.1289/ehp.96104s123.
3
Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N,O-sulfonation in chemical carcinogenesis of aromatic amines.
硫酸化和葡萄糖醛酸化作为异羟肟酸代谢中的竞争途径：N,O-硫酸化在芳香胺化学致癌作用中的作用。
Environ Health Perspect. 1983 Mar;49:27-32. doi: 10.1289/ehp.834927.
4
Acetylation, deacetylation and acyltransfer.乙酰化、去乙酰化和酰基转移
Environ Health Perspect. 1983 Mar;49:43-50. doi: 10.1289/ehp.834943.
5
Perinatal development of conjugative enzyme systems.结合酶系统的围产期发育。
Environ Health Perspect. 1976 Dec;18:25-34. doi: 10.1289/ehp.761825.
6
N-acetyltransferase phenotype and risk in urinary bladder cancer: approaches in molecular epidemiology. Preliminary results in Sweden and Denmark.N-乙酰转移酶表型与膀胱癌风险：分子流行病学方法。瑞典和丹麦的初步结果。
Environ Health Perspect. 1979 Apr;29:71-9. doi: 10.1289/ehp.792971.
7
Metabolic activation/deactivation reactions during perinatal development.围产期发育过程中的代谢激活/失活反应。
Environ Health Perspect. 1979 Apr;29:7-16. doi: 10.1289/ehp.79297.
8
Dual role of glucuronyl- and sulfotransferases converting xenobiotics into reactive or biologically inactive and easily excretable compounds.葡萄糖醛酸基转移酶和磺基转移酶的双重作用，可将外源性物质转化为具有反应活性或无生物活性且易于排泄的化合物。
Arch Toxicol. 1977 Dec 30;39(1-2):77-85. doi: 10.1007/BF00343277.