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Electrophilic N-acetoxyaminoarenes derived from carcinogenic N-hydroxy-N-acetylaminoarenes by enzymatic deacetylation and transacetylation in liver.

作者信息

Bartsch H, Dworkin M, Miller J A, Miller E C

出版信息

Biochim Biophys Acta. 1972 Dec 29;286(2):272-98. doi: 10.1016/0304-4165(72)90265-6.

DOI:10.1016/0304-4165(72)90265-6
PMID:4660457
Abstract
摘要

相似文献

1
Electrophilic N-acetoxyaminoarenes derived from carcinogenic N-hydroxy-N-acetylaminoarenes by enzymatic deacetylation and transacetylation in liver.亲电N-乙酰氧基氨基芳烃是由致癌性N-羟基-N-乙酰氨基芳烃在肝脏中通过酶促脱乙酰化和转乙酰化作用衍生而来的。
Biochim Biophys Acta. 1972 Dec 29;286(2):272-98. doi: 10.1016/0304-4165(72)90265-6.
2
Enzymatic N-acetylation of carcinogenic aromatic amines by liver cytosol of species displaying different organ susceptibilities.不同器官易感性物种的肝脏胞质溶胶对致癌芳香胺的酶促N-乙酰化作用。
Biochem Pharmacol. 1973 Jul 1;22(13):1581-8. doi: 10.1016/0006-2952(73)90024-5.
3
Formation of electrophilic N-acetoxyarylamines in cytosoles from rat mammary gland and other tissues by transacetylation from the carcinogen N-hydroxy-4-acetylaminobiphenyl.
Biochim Biophys Acta. 1973 Mar 30;304(1):42-55. doi: 10.1016/0304-4165(73)90113-x.
4
Acetyl coenzyme A dependent activation of N-hydroxy derivatives of carcinogenic arylamines: mechanism of activation, species difference, tissue distribution, and acetyl donor specificity.致癌芳胺的N-羟基衍生物的乙酰辅酶A依赖性激活：激活机制、种属差异、组织分布及乙酰供体特异性
Cancer Res. 1986 Sep;46(9):4362-7.
5
Sulfotransferase-mediated DNA binding of N-hydroxyarylamines(amide) in liver cytosols from human and experimental animals.
Carcinogenesis. 1992 Aug;13(8):1307-14. doi: 10.1093/carcin/13.8.1307.
6
Activation of the O-glucuronide of the carcinogen N-hydroxy-N-2-fluorenylacetamide by enzymatic deacetylation in vitro: formation of fluorenylamine-tRNA adducts.致癌物N-羟基-N-2-芴基乙酰胺的O-葡糖醛酸在体外经酶促脱乙酰作用激活：芴基胺-tRNA加合物的形成。
Biochem Pharmacol. 1976 May 1;25(9):1051-6. doi: 10.1016/0006-2952(76)90495-0.
7
Acetylation of the carcinogen N-hydroxy-2-acetylaminofluorene by acetyl Coenzyme A to form a reactive ester.致癌物N-羟基-2-乙酰氨基芴被乙酰辅酶A乙酰化，形成一种活性酯。
Mol Pharmacol. 1971 Jul;7(4):381-8.
8
Depression of enzymic esterification of N-hydroxy-AAF in the liver during aminoazo dye carcinogenesis in the rat.大鼠氨基偶氮染料致癌过程中肝脏中N-羟基-AAF酶促酯化作用的抑制。
Res Commun Chem Pathol Pharmacol. 1973 Mar;5(2):421-9.
9
N-hydroxy-2-fluorenylacetamide. Reaction of the carcinogen with guanosine, ribonucleic acid, deoxyribonucleic acid, and protein following enzymatic deacetylation or esterification.
J Biol Chem. 1969 Nov 25;244(22):6209-16.
10
Possible role of the glucuronide conjugate in the biochemical mechanism of binding of the carcinogen N-hydroxy-2-acetylaminofluorene to rat-liver deoxyribonucleic acid in vivo.
Chem Biol Interact. 1969 Oct;1(1):19-26. doi: 10.1016/0009-2797(69)90016-7.

引用本文的文献

1
N-Acetyl-2-Aminofluorene (AAF) Processing in Adult Rat Hepatocytes in Primary Culture Occurs by High-Affinity Low-Velocity and Low-Affinity High-Velocity AAF Metabolite-Forming Systems.N-乙酰-2-氨基芴（AAF）在原代培养的成年大鼠肝细胞中的代谢途径为高亲和力低速度和低亲和力高速度 AAF 代谢产物形成系统。
Toxicol Sci. 2018 May 1;163(1):26-34. doi: 10.1093/toxsci/kfy006.
2
Understanding the gender disparity in bladder cancer risk: the impact of sex hormones and liver on bladder susceptibility to carcinogens.了解膀胱癌风险中的性别差异：性激素和肝脏对膀胱致癌物易感性的影响。
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2013;31(4):287-304. doi: 10.1080/10590501.2013.844755.
3
Characterization of rat hepatic acetyltransferase.
大鼠肝脏乙酰转移酶的特性分析
Environ Health Perspect. 1994 Oct;102 Suppl 6(Suppl 6):91-3. doi: 10.1289/ehp.94102s691.
4
Metabolic activation of aromatic amines and dialkylnitrosamines.芳香胺和二烷基亚硝胺的代谢活化
J Cancer Res Clin Oncol. 1981;99(1-2):125-36. doi: 10.1007/BF00412448.
5
Nonrandom binding of the carcinogen N-hydroxy-2-acetylaminofluorene to repetitive sequences of rat liver DNA in vivo.致癌物N-羟基-2-乙酰氨基芴在体内与大鼠肝脏DNA重复序列的非随机结合。
Proc Natl Acad Sci U S A. 1984 Nov;81(22):6943-7. doi: 10.1073/pnas.81.22.6943.
6
The role of glutathione in detoxication.谷胱甘肽在解毒中的作用。
Environ Health Perspect. 1983 Mar;49:59-69. doi: 10.1289/ehp.834959.
7
Some historical aspects of N-aryl carcinogens and their metabolic activation.N-芳基致癌物及其代谢活化的一些历史方面
Environ Health Perspect. 1983 Mar;49:3-12. doi: 10.1289/ehp.83493.
8
Effect of acetylated and deacetylated 2-aminofluorene adducts on in vitro DNA synthesis.
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7166-70. doi: 10.1073/pnas.79.23.7166.
9
Acetylation, deacetylation and acyltransfer.乙酰化、去乙酰化和酰基转移
Environ Health Perspect. 1983 Mar;49:43-50. doi: 10.1289/ehp.834943.
10
The oxidation of some carcinogenic arylhydroxylamines to nitroso derivatives with manganese dioxide.用二氧化锰将一些致癌芳基羟胺氧化为亚硝基衍生物。
Experientia. 1974 Jul 15;30(7):835. doi: 10.1007/BF01924218.