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大剂量速尿治疗肾病综合征时出现的严重水肿。

Gross oedema in the nephrotic syndrome treated with frusemide in high dosage.

作者信息

Snashall P D

出版信息

Br Med J. 1971 Feb 6;1(5744):319-21. doi: 10.1136/bmj.1.5744.319.

DOI:10.1136/bmj.1.5744.319
PMID:5100264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1794891/
Abstract

Five grossly oedematous patients with nephrotic syndrome required frusemide in doses of 250 mg/day or more. Two cases needed albumin infusions to initiate the diuresis. As oedema was removed renal function improved in four cases. There were no side effects. It is concluded that frusemide in the high doses used is a safe and effective diuretic.

摘要

5例严重水肿的肾病综合征患者需要使用剂量为每日250毫克或更高剂量的速尿。2例患者需要输注白蛋白来启动利尿作用。随着水肿的消退，4例患者的肾功能得到改善。未出现副作用。结论是，所使用的高剂量速尿是一种安全有效的利尿剂。

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本文引用的文献

1
Functional significance of venous blood pressure.静脉血压的功能意义
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2
INTERSTITIAL FLUID PRESURE. II. PRESSURE-VOLUME CURVES OF INTERSTITIAL SPACE .组织间液压力。II. 组织间隙的压力-容积曲线
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Dimensions of blood vessels from distributing artery to collecting vein.从分配动脉到集合静脉的血管尺寸。
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Furosemide, a new diuretic in edematous states. Clinical studies in patients with congestive heart failure and cirrhosis of the liver.
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Potassium supplements.钾补充剂
Br Med J. 1969 Oct 18;4(5676):168. doi: 10.1136/bmj.4.5676.168-b.
7
[Possibilities and limitations of high dosage diuretic therapy in hydropic renal insufficiency].[大剂量利尿疗法在水肿性肾功能不全中的可能性与局限性]
Dtsch Med Wochenschr. 1969 Aug 1;94(31):1568-74. doi: 10.1055/s-0028-1110303.
8
Observations of renal function in patients undergoing therapeutic diuresis with frusemide.使用速尿进行治疗性利尿的患者的肾功能观察。
Clin Sci. 1970 Apr;38(4):439-49. doi: 10.1042/cs0380439.
9
Clinical use of high doses of furosemide (Lasix) in the treatment of resistant nephrotic edema.
Acta Med Scand. 1968 Dec;184(6):473-9. doi: 10.1111/j.0954-6820.1968.tb02488.x.
10
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Ann Intern Med. 1968 Aug;69(2):249-61. doi: 10.7326/0003-4819-69-2-249.