White R J, Chamberlain D A, Howard M, Smith T W
Br Med J. 1971 Feb 13;1(5745):380-1. doi: 10.1136/bmj.1.5745.380.
After the oral administration of 0.5 mg of digoxin in tablet form to fasting subjects peak plasma levels were reached in 30 to 60 minutes. Levels then fell to reach a plateau at six to eight hours. When the same dose was given after food the peak plasma concentrations were significantly lower, but the concentrations reached in samples obtained from two to eight hours after the dose did not differ appreciably from corresponding samples obtained in the fasting experiments.In a four-week cross-over study of 21 patients on maintenance therapy, digoxin taken regularly in the fasting state produced plasma concentrations similar to those obtained when the drug was taken after meals.The rapid appearance of digoxin in the blood suggests that the oral route of administration is adequate for most patients who require rapid digitalization, and the timing of maintenance dosage in relation to meals is unimportant.
给空腹受试者口服0.5毫克片剂地高辛后，30至60分钟达到血浆峰值水平。随后水平下降，在6至8小时达到平稳状态。进食后给予相同剂量时，血浆峰值浓度显著降低，但给药后2至8小时采集的样本中的浓度与空腹实验中相应样本的浓度并无明显差异。在一项针对21名接受维持治疗患者的为期四周的交叉研究中，空腹状态下定期服用地高辛产生的血浆浓度与餐后服用该药时获得的浓度相似。地高辛在血液中快速出现表明，口服给药途径对大多数需要快速洋地黄化的患者来说是足够的，维持剂量与进餐时间的关系并不重要。
