“新”“旧”地高辛吸收、血药浓度及尿排泄的对比研究。
Comparative study of the absorption, plasma levels, and urinary excretion of the "new" and the "old" Lanoxin.
作者信息
Falch D, Teien A, Bjerkelund C J
出版信息
Br Med J. 1973 Mar 24;1(5855):695-7. doi: 10.1136/bmj.1.5855.695.
A comparative study was performed of the absorption, the plasma level at equilibrium, and the urinary excretion of digoxin using two types of Lanoxin tablets, those produced before and after the 1972 alteration of the tablet manufacture.After a single dose the absorption rate of the new tablets was about twice as great as the old, both in young subjects and in the elderly patients. There were no significant differences in the plasma levels of digoxin for the two tablets 15 hours after the last administration in patients on an equal maintenance dose. The urinary excretion of digoxin increased about 40% when the "old" Lanoxin was replaced by the "new." In elderly patients a daily dose of 0.125 mg twice daily of the new tablets should be sufficient to reach the therapeutic range. Young people need a higher dosage. If the kidney function is reduced by as much as 50% the dose should be reduced.
使用两种类型的地高辛片（1972年片剂生产工艺改变前后生产的）对地高辛的吸收、平衡时的血浆水平和尿排泄进行了一项对比研究。单剂量给药后，无论是年轻受试者还是老年患者，新片剂的吸收速率约为旧片剂的两倍。在接受相同维持剂量的患者中，最后一次给药15小时后，两种片剂的地高辛血浆水平无显著差异。当“旧”地高辛被“新”地高辛取代时，地高辛的尿排泄增加了约40%。在老年患者中，每天两次服用0.125毫克新片剂应足以达到治疗范围。年轻人需要更高的剂量。如果肾功能降低多达50%，则应减少剂量。
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