Follath F, Burkart F, Schweizer W
Br Med J. 1971 Jan 30;1(5743):265-6. doi: 10.1136/bmj.1.5743.265.
Of 40 patients with obstructive pulmonary hypertension studied in Basle, Switzerland, during the period 1966-68, 32 had been taking an anorectic drug, aminorex fumarate. Rapidly progressing exertional dyspnoea, central chest pain, and syncope on effort were characteristic features. The absence of the usual causes of pulmonary vascular disease seems to suggest the possibility of drug-induced pulmonary hypertension. Further studies are necessary, however, to clarify the role of aminorex fumarate in this condition.
1966年至1968年期间,在瑞士巴塞尔对40例阻塞性肺动脉高压患者进行了研究,其中32例曾服用一种食欲抑制剂——富马酸氨基苯唑。快速进展的劳力性呼吸困难、心前区疼痛和劳力性晕厥是其特征性表现。缺乏常见的肺血管疾病病因似乎提示药物性肺动脉高压的可能性。然而,需要进一步研究以阐明富马酸氨基苯唑在这种疾病中的作用。