与室性早搏抑制相关的血浆普萘洛尔水平。
Plasma propranolol levels associated with suppression of ventricular ectopic beats.
作者信息
Coltart D J, Gibson D G, Shand D G
出版信息
Br Med J. 1971 Feb 27;1(5747):490-1. doi: 10.1136/bmj.1.5747.490.
Abstract
The plasma propranolol levels associated with the abolition of chronic, stable ventricular ectopic beats have been studied. Racemic propranolol (DL) suppressed the ectopic foci at plasma levels of 40-85 ng/ml in eight patients, but levels of 70-200 ng/ml were unsuccessful in four patients. Dextro-(D) propranolol levels of 180-310 ng/ml were ineffective in four patients who had previously responded at levels of 60-75 ng/ml of racemic propranolol. The significance of the sympathetic nervous system in the genesis of ectopic beats is discussed. It is concluded that propranolol is clinically effective by virtue of its beta-adrenergic blocking activity.
摘要
已对与消除慢性、稳定性室性异位搏动相关的血浆普萘洛尔水平进行了研究。消旋普萘洛尔（DL）在8例患者中，血浆水平为40 - 85 ng/ml时可抑制异位灶，但在4例患者中，70 - 200 ng/ml的水平却未成功。4例患者中，右（D）普萘洛尔水平为180 - 310 ng/ml时无效，而这些患者此前在消旋普萘洛尔水平为60 - 75 ng/ml时曾有反应。文中讨论了交感神经系统在异位搏动发生中的意义。得出的结论是，普萘洛尔因其β - 肾上腺素能阻断活性而具有临床疗效。
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