牛胰凝乳蛋白酶A-γ中的底物结合位点。使用肽氯甲基酮作为位点特异性抑制剂的晶体学研究。 - Suppr

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超能文献

Substrate binding site in bovine chymotrypsin A-gamma. A crystallographic study using peptide chloromethyl ketones as site-specific inhibitors.

作者信息

Segal D M, Powers J C, Cohen G H, Davies D R, Wilcox P E

出版信息

Biochemistry. 1971 Sep 28;10(20):3728-38. doi: 10.1021/bi00796a014.

DOI:10.1021/bi00796a014

PMID:5107010

Abstract

摘要

相似文献

Substrate binding site in bovine chymotrypsin A-gamma. A crystallographic study using peptide chloromethyl ketones as site-specific inhibitors.牛胰凝乳蛋白酶A-γ中的底物结合位点。使用肽氯甲基酮作为位点特异性抑制剂的晶体学研究。

Biochemistry. 1971 Sep 28;10(20):3728-38. doi: 10.1021/bi00796a014.

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Kinetics of the reaction of chymotrypsin A with peptide chloromethyl ketones in relation to its subsite specificity.胰凝乳蛋白酶A与肽氯甲基酮反应的动力学及其亚位点特异性

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The topographical differences in the active site region of alpha-chymotrypsin, subtilisin Novo, and subtilisin Carlsberg. Mapping the aromatic binding site by inhibitors (virtual substrates).α-胰凝乳蛋白酶、嗜热栖热菌蛋白酶和枯草杆菌蛋白酶卡尔伯格活性位点区域的拓扑差异。通过抑制剂（虚拟底物）绘制芳香族结合位点。

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An x-ray crystallographic study of the binding of peptide chloromethyl ketone inhibitors to subtilisin BPN'.肽氯甲基酮抑制剂与枯草杆菌蛋白酶BPN'结合的X射线晶体学研究。

Biochemistry. 1972 Jun 20;11(13):2439-49. doi: 10.1021/bi00763a009.

A kinetic investigation of the crystallographically deduced binding subsites of bovine chymotrypsin A .牛胰凝乳蛋白酶A晶体学推导的结合亚位点的动力学研究。

Biochemistry. 1972 Feb 1;11(3):349-56. doi: 10.1021/bi00753a007.

Preparation and kinetic properties of a new form of chymotrypsin which is active at alkaline pH: 1 -chymotrypsin.一种在碱性pH下具有活性的新型胰凝乳蛋白酶的制备及其动力学性质：1-胰凝乳蛋白酶。

J Biol Chem. 1973 Jul 25;248(14):4909-14.

The aromatic substrate binding site in subtilisin BPN' and its resemblance to chymotrypsin.枯草杆菌蛋白酶BPN'中的芳香族底物结合位点及其与胰凝乳蛋白酶的相似性。

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The study of alpha-chymotrypsin by x-ray diffraction. The Third CIBA Medal Lecture.通过X射线衍射对α-胰凝乳蛋白酶的研究。第三届西巴奖章讲座。

Biochem J. 1969 Apr;112(3):261-8. doi: 10.1042/bj1120261.

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13C high-resolution nuclear magnetic resonance studies of enzyme-substrate reactions at equilibrium. Substrate studies of chymotrypsin-N-acetyltyrosine semicarbazide complexes.平衡状态下酶 - 底物反应的13C高分辨率核磁共振研究。胰凝乳蛋白酶 - N - 乙酰酪氨酸氨基脲复合物的底物研究。

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Site-directed mutagenesis and the role of the oxyanion hole in subtilisin.

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Isolation and sequence analysis of serine protease cDNAs from mouse cytolytic T lymphocytes.从小鼠细胞毒性T淋巴细胞中分离丝氨酸蛋白酶cDNA并进行序列分析。

J Exp Med. 1988 Nov 1;168(5):1839-54. doi: 10.1084/jem.168.5.1839.

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.人中性粒细胞弹性蛋白酶与一种肽氯甲基酮抑制剂复合物在1.84埃分辨率下的结构。

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