Eckel R H, Fujimoto W Y, Brunzell J D
Diabetes. 1979 Dec;28(12):1141-2. doi: 10.2337/diab.28.12.1141.
Fat feeding stimulated the release of gastric inhibitory polypeptide (GIP) without concomitant insulin secretion. Since antilipolytic effects of GIP have been demonstrated and the uptake of triglyceride fatty acid by adipose tissue postprandially is a process reciprocally regulated with lipolysis, a stimulatory role of GIP on adipose tissue lipoprotein lipase activity may be present. After cultured preadipocytes were incubated for 2 h with GIP, the release of lipoprotein lipase activity into the culture medium and the total cellular activity present in acetone-ether powders of cells were measured. GIP stimulated significant increases in the lipoprotein lipase activity released into the culture medium and in cells. A dose response relationship was strongest for the effect of GIP on the enzyme activity in extracts of acetone-ether powders of the cells. The increased lipoprotein lipase activity produced by GIP could provide a mechanisms for clearance of chylomicron triglyceride after feeding in man.
脂肪喂养刺激了胃抑制多肽（GIP）的释放，同时却没有伴随胰岛素分泌。由于已证实GIP具有抗脂解作用，且餐后脂肪组织对甘油三酯脂肪酸的摄取是一个与脂解相互调节的过程，因此GIP可能对脂肪组织脂蛋白脂肪酶活性具有刺激作用。将培养的前脂肪细胞与GIP孵育2小时后，测定了释放到培养基中的脂蛋白脂肪酶活性以及细胞丙酮 - 乙醚粉末中存在的总细胞活性。GIP刺激了释放到培养基中和细胞中的脂蛋白脂肪酶活性显著增加。GIP对细胞丙酮 - 乙醚粉末提取物中酶活性的影响，剂量反应关系最为明显。GIP产生的脂蛋白脂肪酶活性增加，可能为人体进食后乳糜微粒甘油三酯的清除提供一种机制。
