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4-Ketocyclophosphamide, a metabolite of cyclophosphamide. Formation, chemical and biological properties.

作者信息

Hohorst H J, Ziemann A, Brock N

出版信息

Arzneimittelforschung. 1971 Aug;21(8):1254-7.

PMID:5110030
Abstract
摘要

相似文献

1
4-Ketocyclophosphamide, a metabolite of cyclophosphamide. Formation, chemical and biological properties.4-酮环磷酰胺，环磷酰胺的一种代谢产物。形成、化学及生物学特性。
Arzneimittelforschung. 1971 Aug;21(8):1254-7.
2
[Effects of enzyme inducers in various organs and animals on cyclophosphamide activation to mutagenic products in vitro].[酶诱导剂对不同器官及动物体内环磷酰胺在体外活化为诱变产物的影响]
G Ital Chemioter. 1984 Jan-Aug;31(1-2):77-80.
3
Modification of the mutagenicity and teratogenicity of cyclophosphamide in rats with inducers of the cytochromes P-450.细胞色素P - 450诱导剂对大鼠体内环磷酰胺致突变性和致畸性的影响
Teratology. 1981 Aug;24(1):1-11. doi: 10.1002/tera.1420240102.
4
Relative mutagenicity of some urinary metabolites of the antitumor drug cyclophosphamide.抗肿瘤药物环磷酰胺某些尿液代谢物的相对诱变性。
Cancer Res. 1981 Jul;41(7):2967-72.
5
In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity.P-450催化的环磷酰胺代谢旁路的体内调节：对药代动力学和抗肿瘤活性的影响。
J Pharmacol Exp Ther. 1999 Mar;288(3):928-37.
6
Isolation and identification of a metabolic intermediate in the selective dechloroethylation of one of the four stereoisomers of 4-methylcyclophosphamide.4-甲基环磷酰胺四种立体异构体之一的选择性脱氯乙基化过程中一种代谢中间体的分离与鉴定。
Cancer Res. 1978 Aug;38(8):2592-9.
7
Mechanism of cyclophosphamide transport by L5178Y lymphoblasts in vitro.
Cancer Res. 1974 Dec;34(12):3274-82.
8
Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite.
Cancer Res. 1972 Apr;32(4):658-65.
9
Bioassay and relative cytotoxic potency of cyclophosphamide metabolites generated in vitro and in vivo.体外和体内生成的环磷酰胺代谢产物的生物测定及相对细胞毒性效力
Cancer Res. 1973 Jun;33(6):1150-8.
10
Iminocyclophosphamide as a chemically reactive metabolite of cyclophosphamide.异环磷酰胺作为环磷酰胺的化学反应性代谢产物。
Drug Metab Dispos. 1982 Nov-Dec;10(6):636-40.

引用本文的文献

1
Proton magnetic resonance studies of the decomposition of 4-hydroxycyclophosphamide, a microsomal metabolite of cyclophosphamide.质子磁共振研究 4-羟基环磷酰胺的分解，环磷酰胺的一种微粒体代谢物。
Pharm Res. 1984 Mar;1(2):89-92. doi: 10.1023/A:1016307515811.
2
Clinical pharmacokinetics of cyclophosphamide.环磷酰胺的临床药代动力学
Clin Pharmacokinet. 2005;44(11):1135-64. doi: 10.2165/00003088-200544110-00003.
3
Excretion patterns of alkylating metabolites in urine following cyclophosphamide treatment of tumor patients: influence of application route, dosage, liver and kidney function.
J Cancer Res Clin Oncol. 1979 Jul 27;94(3):277-86. doi: 10.1007/BF00419287.
4
[Fluorometric determination of "activated" cyclophosphamide and ifosfamide in blood (author's transl)].
J Cancer Res Clin Oncol. 1979 Apr 12;93(3):233-40. doi: 10.1007/BF00964578.
5
[The evaluation of the cyclophosphamide sensitivity of human tumours by determining the incorporation of tritiated uridine and thymidine into the nucleic acids of human tumor cells in vitro in presence of 4-hydroxycyclophosphamide (author's transl)].通过在4-羟基环磷酰胺存在的情况下，在体外测定氚标记的尿苷和胸苷掺入人肿瘤细胞核酸中的情况来评估人肿瘤对环磷酰胺的敏感性（作者译）
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Sep 22;84(1):37-47. doi: 10.1007/BF00305687.
6
[In vitro assay for cyclophosphamide-sensitivity of human tumours: the effect of 4-hydro-peroxy-cyclophosphamide on the incorporation of 3H-uridine into the nucleic acids of human tumour cells (author's transl)].人肿瘤对环磷酰胺敏感性的体外测定：4-氢过氧环磷酰胺对3H-尿苷掺入人肿瘤细胞核酸的影响（作者译）
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Mar 19;85(3):299-307. doi: 10.1007/BF00284088.