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Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite.

作者信息

Hill D L, Laster W R, Struck R F

出版信息

Cancer Res. 1972 Apr;32(4):658-65.

PMID:5014778
Abstract
摘要

相似文献

1
Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite.
Cancer Res. 1972 Apr;32(4):658-65.
2
Enzymatic basis of cyclophosphamide activation by hepatic microsomes of the rat.大鼠肝脏微粒体对环磷酰胺激活作用的酶学基础。
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3
Metabolism of iphosphamide (2-(2-chloroethylamino)-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide) and production of a toxic iphosphamide metabolite.
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Urinary metabolites of the antitumor agent cyclophosphamide.抗肿瘤药物环磷酰胺的尿液代谢产物。
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5
Therapeutic efficacy of cyclophosphamide as a function of its metabolism.环磷酰胺的治疗效果与其代谢的关系。
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6
Influence of inducers of monooxygenases on cytotoxic efficiency of ellipticine on leukemia L1210 cells.单加氧酶诱导剂对椭圆玫瑰树碱抗白血病L1210细胞细胞毒作用的影响。
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The effect of phenobarbital or 2-diethylaminoethyl-2,2-diphenylvalerate on the activation of cyclophosphamide in vivo.苯巴比妥或2-二乙氨基乙基-2,2-二苯基戊酸酯对环磷酰胺体内活化的影响。
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Effect of phenobarbital and SKF 525A on placental transfer of cyclophosphamide in mice.
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Role of aldehyde dehydrogenase in the metabolism-dependent biological activity of cyclophosphamide.醛脱氢酶在环磷酰胺代谢依赖性生物学活性中的作用。
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Participation of the microsomal electron transport system involving cytochrome P-450 in 7alpha-hydroxylation of cholesterol.涉及细胞色素P-450的微粒体电子传递系统参与胆固醇的7α-羟化作用。
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Front Behav Neurosci. 2021 Oct 21;15:758252. doi: 10.3389/fnbeh.2021.758252. eCollection 2021.
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Building predictive in vitro pulmonary toxicity assays using high-throughput imaging and artificial intelligence.利用高通量成像和人工智能构建预测性体外肺毒性检测方法。
Arch Toxicol. 2018 Jun;92(6):2055-2075. doi: 10.1007/s00204-018-2213-0. Epub 2018 Apr 28.
3
Proton magnetic resonance studies of the decomposition of 4-hydroxycyclophosphamide, a microsomal metabolite of cyclophosphamide.
质子磁共振研究 4-羟基环磷酰胺的分解，环磷酰胺的一种微粒体代谢物。
Pharm Res. 1984 Mar;1(2):89-92. doi: 10.1023/A:1016307515811.
4
Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QTOFMS-based metabolomics.基于 UPLC-ESI-QTOFMS 的代谢组学研究在小鼠体内环磷酰胺和异环磷酰胺的比较代谢。
Biochem Pharmacol. 2010 Oct 1;80(7):1063-74. doi: 10.1016/j.bcp.2010.06.002. Epub 2010 Jun 10.
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Clinical pharmacokinetics of cyclophosphamide.环磷酰胺的临床药代动力学
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Preclinical pharmacokinetics and stability of isophosphoramide mustard.异环磷酰胺氮芥的临床前药代动力学与稳定性
Cancer Chemother Pharmacol. 1994;33(5):391-8. doi: 10.1007/BF00686268.
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Pharmacokinetic drug interactions with anticancer drugs.抗癌药物的药代动力学药物相互作用。
Clin Pharmacokinet. 1994 Jun;26(6):486-500. doi: 10.2165/00003088-199426060-00006.
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The metabolism of nicotine-delta 1'(5')-iminium ion, in vivo and in vitro.
Eur J Drug Metab Pharmacokinet. 1982 Oct-Dec;7(4):293-8. doi: 10.1007/BF03189632.
9
Pharmacokinetics of high-dose cyclophosphamide in patients with metastatic bronchogenic carcinoma.高剂量环磷酰胺在转移性支气管癌患者中的药代动力学
Cancer Chemother Pharmacol. 1983;11(3):196-9. doi: 10.1007/BF00254204.
10
In vitro microassay for biological activity of cyclophosphamide metabolites.环磷酰胺代谢物生物活性的体外微量测定
Antimicrob Agents Chemother. 1973 Mar;3(3):407-11. doi: 10.1128/AAC.3.3.407.