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内皮细胞再生的体内和体外研究。

In vivo and in vitro studies on endothelial regeneration.

作者信息

Clopath P, Müller K, Stäubli W, Bürk R R

出版信息

Haemostasis. 1979;8(3-5):149-57. doi: 10.1159/000214307.

DOI:10.1159/000214307
PMID:511007
Abstract

Endothelial regeneration was studied in rabbit aorta after intra-arterial balloon catheterization. Most of the regenerated endothelium originated from existing branches which was assessed by the Evans-blue uptake pattern and confirmed by transmission and scanning electron microscopy. Glucocorticoid treatment enhanced re-endothelialization whereas hyperlipemic diet inhibited. Sera from minipigs fed an atherogenic diet consistently have less ability than sera from control pigs to stimulate in vitro the regeneration of wounded endothelium-like monolayers of 3T3-B cells. The deficiency is probably due to an inhibitor which appears and disappears with changes in the diet.

摘要

通过动脉内球囊导管插入术研究兔主动脉内皮再生情况。多数再生内皮起源于现存分支,这通过伊文思蓝摄取模式评估,并经透射和扫描电子显微镜证实。糖皮质激素治疗可促进再内皮化,而高脂饮食则起抑制作用。喂食致动脉粥样化饮食的小型猪血清刺激3T3 - B细胞损伤内皮样单层体外再生的能力始终低于对照猪血清。这种缺陷可能是由于一种随饮食变化而出现和消失的抑制剂所致。

相似文献

1
In vivo and in vitro studies on endothelial regeneration.内皮细胞再生的体内和体外研究。
Haemostasis. 1979;8(3-5):149-57. doi: 10.1159/000214307.
2
Ultrastructural changes in re-endothelialized and non-endothelialized rabbit aortic neo-intima following re-injury with a balloon catheter.球囊导管再次损伤后兔主动脉再内皮化和未内皮化新生内膜的超微结构变化
Br J Exp Pathol. 1984 Oct;65(5):597-611.
3
Repair in arterial tissue. 2. Connective tissue changes following an embolectomy catheter lesion. The importance of the endothelial cells to repair and regeneration.动脉组织的修复。2. 取栓导管损伤后结缔组织的变化。内皮细胞对修复和再生的重要性。
Acta Pathol Microbiol Scand A. 1979 Jul;87A(4):275-83.
4
Maintenance of integrity in aortic endothelium.主动脉内皮完整性的维持。
Fed Proc. 1980 Jul;39(9):2618-25.
5
Repair in arterial tissue. Endothelial regrowth, subendothelial tissue changes and permeability in the healing rabbit thoracic aorta.动脉组织修复。愈合过程中兔胸主动脉的内皮再生、内皮下组织变化及通透性
Acta Pathol Microbiol Scand A. 1979 Jul;87A(4):265-73.
6
The pattern of endothelial cell boundaries in regenerated aortae.再生主动脉中内皮细胞边界的模式。
Experientia. 1979 Oct 15;35(10):1390-1. doi: 10.1007/BF01964026.
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[Changes in the endothelium of the aorta of the rat during regeneration (according to the results of scanning electron microscopy)].[大鼠主动脉内皮在再生过程中的变化(根据扫描电子显微镜检查结果)]
Arkh Anat Gistol Embriol. 1985 Oct;89(10):54-60.
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Ultrastructural studies of the mouse aorta and its endothelial pinocytosis in diet-induced arteriosclerosis.饮食诱导的动脉粥样硬化中小鼠主动脉及其内皮细胞胞饮作用的超微结构研究。
Acta Pathol Jpn. 1983 Nov;33(6):1115-30. doi: 10.1111/j.1440-1827.1983.tb02157.x.
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Endothelial regeneration. III. Time course of intimal changes after small defined injury to rat aortic endothelium.内皮再生。III. 大鼠主动脉内皮受到小范围特定损伤后内膜变化的时间进程。
Lab Invest. 1981 Apr;44(4):301-8.
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Ultrastructural features of healing and scarring of experimental atheroma.实验性动脉粥样硬化愈合与瘢痕形成的超微结构特征
Adv Exp Med Biol. 1984;168:37-50. doi: 10.1007/978-1-4684-4646-3_3.

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