Clopath P, Müller K, Stäubli W, Bürk R R
Haemostasis. 1979;8(3-5):149-57. doi: 10.1159/000214307.
Endothelial regeneration was studied in rabbit aorta after intra-arterial balloon catheterization. Most of the regenerated endothelium originated from existing branches which was assessed by the Evans-blue uptake pattern and confirmed by transmission and scanning electron microscopy. Glucocorticoid treatment enhanced re-endothelialization whereas hyperlipemic diet inhibited. Sera from minipigs fed an atherogenic diet consistently have less ability than sera from control pigs to stimulate in vitro the regeneration of wounded endothelium-like monolayers of 3T3-B cells. The deficiency is probably due to an inhibitor which appears and disappears with changes in the diet.
通过动脉内球囊导管插入术研究兔主动脉内皮再生情况。多数再生内皮起源于现存分支,这通过伊文思蓝摄取模式评估,并经透射和扫描电子显微镜证实。糖皮质激素治疗可促进再内皮化,而高脂饮食则起抑制作用。喂食致动脉粥样化饮食的小型猪血清刺激3T3 - B细胞损伤内皮样单层体外再生的能力始终低于对照猪血清。这种缺陷可能是由于一种随饮食变化而出现和消失的抑制剂所致。