腺病毒感染的HeLa细胞中痘苗病毒复制的抑制机制。
Mechanism of inhibition of vaccinia virus replication in adenovirus-infected HeLa cells.
作者信息
Giorno R, Kates J R
出版信息
J Virol. 1971 Feb;7(2):208-13. doi: 10.1128/JVI.7.2.208-213.1971.
Abstract
The ability of vaccinia virus to replicate in HeLa cells which had been previously infected with adenovirus type 2 (Ad2) was studied in order to gain insight into the mechanism by which adenovirus inhibits the expression of host cell functions. Vaccinia virus was employed in these studies because it replicates in the cytoplasm, whereas Ad2 replicates in the nucleus of the cell. It was found that vaccinia deoxyribonucleic acid (DNA) synthesis is greatly inhibited in adeno-preinfected HeLa cells provided that vaccinia superinfection does not occur before 18 hr after adeno infection. The inhibition of vaccinia DNA synthesis can be traced to an inhibition of vaccinia protein synthesis and viral uncoating. Vaccinia ribonucleic acid (RNA) synthesis is not inhibited in adeno-preinfected cells, but the vaccinia RNA does not become associated with polysomes.
摘要
为深入了解腺病毒抑制宿主细胞功能表达的机制，研究了痘苗病毒在先前感染过2型腺病毒（Ad2）的HeLa细胞中的复制能力。在这些研究中使用痘苗病毒是因为它在细胞质中复制，而Ad2在细胞核中复制。结果发现，只要痘苗病毒在腺病毒感染后18小时之前没有发生超感染，那么在预先感染腺病毒的HeLa细胞中，痘苗病毒脱氧核糖核酸（DNA）的合成会受到极大抑制。痘苗病毒DNA合成的抑制可追溯到痘苗病毒蛋白质合成和病毒脱壳的抑制。在预先感染腺病毒的细胞中，痘苗病毒核糖核酸（RNA）的合成未受抑制，但痘苗病毒RNA不会与多核糖体结合。
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