Molavi A, Weinstein L
Appl Microbiol. 1971 Jul;22(1):23-5. doi: 10.1128/am.22.1.23-25.1971.
Atypical mycobacteria (209 strains) were examined for susceptibility to rifampin by the proportion method by using Middlebrook 7H-10 agar. All strains of Mycobacterium kansasii and tap-water scotochromogens were inhibited by 0.25 to 1 mug of the drug per ml. Seventy-six per cent of M. scrofulaceum and 61% of M. intracellulare strains were susceptible to 4 mug/ml or less; 5% of the former and 8% of the latter were resistant to 16 mug/ml. All strains of M. gastri and M. triviale and most strains of M. terrae were sensitive to 1 to 4 mug/ml. Two strains of M. borstelense were both inhibited by 8 mug/ml. Nearly all strains of M. fortuitum were resistant to the drug. The results of this study suggest that rifampin may be a valuable agent for the treatment of many atypical mycobacterial infections.
采用比例法，以Middlebrook 7H - 10琼脂对209株非典型分枝杆菌进行利福平药敏试验。堪萨斯分枝杆菌和自来水产色分枝杆菌的所有菌株均被每毫升0.25至1微克的该药物所抑制。76%的瘰疬分枝杆菌菌株和61%的胞内分枝杆菌菌株对4微克/毫升及以下的药物敏感；前者的5%和后者的8%对16微克/毫升耐药。胃分枝杆菌和琐事分枝杆菌的所有菌株以及大部分地分枝杆菌菌株对1至4微克/毫升敏感。两株博斯特尔分枝杆菌均被8微克/毫升抑制。几乎所有偶然分枝杆菌菌株对该药物耐药。本研究结果提示，利福平可能是治疗许多非典型分枝杆菌感染的有效药物。
