Woodley C L, Kilburn J O, David H L, Silcox V A
Antimicrob Agents Chemother. 1972 Oct;2(4):245-9. doi: 10.1128/AAC.2.4.245.
The Mycobacterium species M. tuberculosis, M. avium-intracellulare, M. kansasii, M. marinum, M. scrofulaceum, M. fortuitum, M. terrae, and M. gordonae were analyzed for their susceptibility to rifampin. M. tuberculosis, M. kansasii, and M. marinum were susceptible to the antibiotic, and resistant populations developed as a result of the interplay of mutation and selection. The mutation rates (susceptibility --> resistance) were calculated to be 4.9 x 10(-10) and 1.7 x 10(-9) mutations per bacterium per generation in, respectively, M. kansasii and M. marinum. M. fortuitum was found to be naturally resistant to the antibiotic, whereas the nature of resistance in the other species was unclear and is discussed.
对结核分枝杆菌、鸟分枝杆菌复合群、堪萨斯分枝杆菌、海分枝杆菌、瘰疬分枝杆菌、偶然分枝杆菌、地分枝杆菌和戈登分枝杆菌等分枝杆菌属菌种进行了利福平敏感性分析。结核分枝杆菌、堪萨斯分枝杆菌和海分枝杆菌对该抗生素敏感，耐药菌群体是突变与选择相互作用的结果。堪萨斯分枝杆菌和海分枝杆菌的突变率（敏感→耐药）经计算分别为每代每菌4.9×10⁻¹⁰和1.7×10⁻⁹个突变。发现偶然分枝杆菌对该抗生素天然耐药，而其他菌种的耐药性质尚不清楚并予以讨论。
