控制δ-氨基-γ-酮戊酸脱水酶合成速率和结构的基因的连锁
Linkage of genes controlling the rate of synthesis and structure of aminolevulinate dehydratase.
作者信息
Coleman D L
出版信息
Science. 1971 Sep 24;173(4003):1245-6. doi: 10.1126/science.173.4003.1245.
PMID:5111568
Abstract
The rate of synthesis of delta-aminolevulinate dehydratase in mice is controlled by alleles at the levulinate (Lv) locus. Two structural mutations modifying the sensitivity of delta-aminolevulinate dehydratase to heat have been identified. Genetic analyses established that the structural locus for delta-aminolevulinate dehydratase was either physically close to or identical with the locus that controls its rate of synthesis.
摘要
小鼠中δ-氨基乙酰丙酸脱水酶的合成速率受乙酰丙酸（Lv）位点上等位基因的控制。已鉴定出两种改变δ-氨基乙酰丙酸脱水酶对热敏感性的结构突变。遗传分析表明，δ-氨基乙酰丙酸脱水酶的结构位点要么在物理上与控制其合成速率的位点紧密相连，要么与之相同。
Zotero 插件