小鼠下颌下腺蛋白酶基因座（TAM-1）的遗传变异及其在7号染色体上的定位。
Genetic variation at a locus (TAM-1) for submaxillary gland protease in the mouse and its location on chromosome No. 7.
作者信息
Skow L C
出版信息
Genetics. 1978 Dec;90(4):713-24. doi: 10.1093/genetics/90.4.713.
Abstract
Electrophoretic and activity variants for a testosterone-induced esteroprotease have been discovered in submaxillary glands from inbred strains of mice. The enzyme is tentatively designated tamase [TAM-1] and the variant genetic locus is Tam-1. The alleles Tam-1a and Tam-1b determine electrophoretically distinct zones of tamase activity, while Tam-lc produces no detectable enzyme activity. Data from recombinant inbred strains and B6AF1 X B6 and B6D2F1 X B6 backcrosses established linkage of Tam-1 to glucose phosphate isomerase (Gpi-1), pink-eyed dilution [p] and beta-hemoglobin (Hbb) on chromosome 7. The gene order is Gpi-1--Tam-1--p--HBB. Analysis of congenic resistant strains indicates that Tam-1 is closely linked to the minor histocompatibility locus, H-4. TAM-1 was not cross-reactive with antisera to mouse nerve growth factor, submaxillary renin, or tamases A and D.
摘要
在近交系小鼠的颌下腺中发现了一种睾酮诱导的酯蛋白酶的电泳变体和活性变体。该酶暂定为tamase [TAM-1]，变体基因座为Tam-1。等位基因Tam-1a和Tam-1b决定了tamase活性的电泳不同区域，而Tam-lc不产生可检测到的酶活性。来自重组近交系以及B6AF1×B6和B6D2F1×B6回交的数据确定了Tam-1与7号染色体上的葡萄糖磷酸异构酶（Gpi-1）、粉红眼稀释基因[p]和β-血红蛋白（Hbb）的连锁关系。基因顺序为Gpi-1--Tam-1--p--HBB。对同源抗性品系的分析表明，Tam-1与次要组织相容性位点H-4紧密连锁。TAM-1与针对小鼠神经生长因子、颌下肾素或tamases A和D的抗血清无交叉反应。
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