Pohl J E, Thurston H
Br Med J. 1971 Oct 16;4(5780):142-5. doi: 10.1136/bmj.4.5780.142.
Treatment with intravenous and oral diazoxide was given to a group of 39 patients suffering from severe drug-resistant hypertension associated with renal impairment. Rapid initial and good long-term control of hypertension was achieved in all cases without the production of clinically significant postural hypotension. The side effects of diazoxide, including its diabetogenic effect, were easily controlled. There was a highly significant improvement in renal function in most patients on long-term oral diazoxide therapy.Diazoxide may have an important place in both the short- and long-term therapy of resistant hypertension, particularly in association with renal damage.
对39例患有与肾功能损害相关的严重耐药性高血压的患者进行了静脉和口服二氮嗪治疗。所有病例均实现了高血压的快速初始良好长期控制，且未产生具有临床意义的体位性低血压。二氮嗪的副作用，包括其致糖尿病作用，易于控制。大多数接受长期口服二氮嗪治疗的患者肾功能有极显著改善。二氮嗪在耐药性高血压的短期和长期治疗中可能都占有重要地位，尤其是在伴有肾损害的情况下。
