交感神经系统在大鼠肾性高血压发展中的重要性。
Importance of the sympathetic nervous system in the development of renal hypertension in the rat.
作者信息
Grewal R S, Kaul C L
出版信息
Br J Pharmacol. 1971 Aug;42(4):497-504. doi: 10.1111/j.1476-5381.1971.tb07135.x.
Abstract
- Chemical sympathectomy with 6-hydroxydopamine (6-OHDA) prevented the development of renal hypertension in 80% of weanling male rats of the C.F. strain.2. Adult male rats treated with 6-OHDA developed hypertension on bilateral clamping of the renal arteries.3. Demedullation of the adrenal glands followed by 6-OHDA treatment in adult rats prevented the development of hypertension in 75% of them.4. Weanling rats treated with 6-OHDA did not have any measurable catecholamines in their hearts up to 72-78 days after treatment.5. Unlike the weanling rats, the hearts of adult rats (demedullated or with intact medulla) showed significant refilling (40-50%) of catecholamine stores 60 days after 6-OHDA treatment.6. It is concluded that the functional sympathetic nervous system is important in the development of renal hypertension in the rat.
摘要
用6-羟基多巴胺（6-OHDA）进行化学性交感神经切除术可防止80%的C.F.品系断奶雄性大鼠发生肾性高血压。
用6-OHDA处理的成年雄性大鼠在双侧肾动脉夹闭后出现高血压。
成年大鼠肾上腺去髓质后再用6-OHDA处理，75%的大鼠可防止高血压的发生。
用6-OHDA处理的断奶大鼠在处理后72至78天内心脏中未检测到任何可测量的儿茶酚胺。
与断奶大鼠不同，成年大鼠（去髓质或髓质完整）的心脏在6-OHDA处理60天后儿茶酚胺储存有显著的再填充（40-50%）。
得出的结论是，功能性交感神经系统在大鼠肾性高血压的发生中很重要。
相似文献
1
Importance of the sympathetic nervous system in the development of renal hypertension in the rat.交感神经系统在大鼠肾性高血压发展中的重要性。
Br J Pharmacol. 1971 Aug;42(4):497-504. doi: 10.1111/j.1476-5381.1971.tb07135.x.
2
Role of sympathetic nervous system in experimental hypertension and diabetes mellitus.交感神经系统在实验性高血压和糖尿病中的作用。
Clin Exp Hypertens. 1999 Jan-Feb;21(1-2):95-112. doi: 10.3109/10641969909068653.
3
Is the peripheral sympatho-adrenal nervous system necessary for renal hypertension?肾性高血压是否需要外周交感 - 肾上腺神经系统？
J Pharmacol Exp Ther. 1976 Jan;196(1):35-43.
4
Plasma catecholamines, cyclic AMP and metabolic substrates in hemorrhagic shock of the rat. The effect of adrenal demedullation and 6-OH-dopamine treatment.大鼠失血性休克时的血浆儿茶酚胺、环磷酸腺苷及代谢底物。肾上腺髓质切除及6-羟基多巴胺处理的影响。
Acta Physiol Scand. 1979 Apr;105(4):481-95. doi: 10.1111/j.1748-1716.1979.tb00113.x.
5
The effect of bilateral adrenal demedullation on vascular reactivity and blood pressure in spontaneously hypertensive rats.双侧肾上腺髓质剥除术对自发性高血压大鼠血管反应性和血压的影响。
Br J Pharmacol. 1983 Nov;80(3):429-37. doi: 10.1111/j.1476-5381.1983.tb10712.x.
6
Differential development of salt-induced and renal hypertension in Dahl hypertension-sensitive rats after neonatal sympathectomy.
Clin Exp Hypertens (1978). 1979;1(6):779-99. doi: 10.3109/10641967909068639.
7
The contribution of the sympathetic nervous system to the development and maintenance of experimental hypertension in the rat.交感神经系统对大鼠实验性高血压发生和维持的作用。
Br J Pharmacol. 1970 Jun;39(2):317-24. doi: 10.1111/j.1476-5381.1970.tb12895.x.
8
Physostigmine- and 1,1-dimethyl-4-phenylpiperazinium-induced pressor responses and catecholamine release in 6-hydroxydopamine-treated rats.毒扁豆碱和1,1 - 二甲基 - 4 - 苯基哌嗪在6 - 羟基多巴胺处理的大鼠中引起的升压反应和儿茶酚胺释放。
Eur J Pharmacol. 1972 May;18(2):261-5. doi: 10.1016/0014-2999(72)90251-8.
9
Interrelationship between angiotensin and catecholamines.
Jpn Heart J. 1968 Jan;9(1):13-9. doi: 10.1536/ihj.9.13.
引用本文的文献
1
Dexamethasone Causes Hypertension in Rats Even Under Chemical Blockade of Peripheral Sympathetic Nerves.即使在对外周交感神经进行化学阻断的情况下，地塞米松仍会导致大鼠高血压。
Front Neurosci. 2019 Dec 6;13:1305. doi: 10.3389/fnins.2019.01305. eCollection 2019.
2
The importance of central adrenergic neurones in renal hypertension in rabbits.中枢肾上腺素能神经元在兔肾性高血压中的重要性。
J Physiol. 1974 Apr;238(2):403-11. doi: 10.1113/jphysiol.1974.sp010532.
本文引用的文献
1
A plethysmographic method for measuring systolic blood pressure in the intact rat.一种用于测量完整大鼠收缩压的体积描记法。
J Physiol. 1938 Aug 15;93(3):301-4. doi: 10.1113/jphysiol.1938.sp003641.
2
MONOAMINES IN IMMUNOSYMPATHECTOMIZED RATS.免疫交感神经切除大鼠体内的单胺类物质
Int J Neuropharmacol. 1965 Apr;4:91-5. doi: 10.1016/0028-3908(65)90032-8.
3
DIFFERENCES IN LEVELS OF CIRCULATING VASOPRESSOR MATERIALS IN DOGS WITH ACUTE AND CHRONIC RENAL HYPERTENSION.
Proc Soc Exp Biol Med. 1964 Oct;117:127-31. doi: 10.3181/00379727-117-29514.
4
VASOPRESSOR MATERIAL IN EXPERIMENTAL RENAL HYPERTENSION.
Circ Res. 1963 Dec;13:552-6. doi: 10.1161/01.res.13.6.552.
5
Neurogenic control of peripheral resistance in renal hypertension.
Circ Res. 1963 May;12(5) Pt 2:562-72. doi: 10.1161/01.res.12.5.562.
6
Observations on the pathogenesis of spontaneous inherited hypertension and constricted renalartery hypertension in rats.
Circ Res. 1961 Mar;9:455-64. doi: 10.1161/01.res.9.2.455.
7
Norepinephrine metabolism in rat brain and heart.大鼠脑和心脏中的去甲肾上腺素代谢
J Pharmacol Exp Ther. 1961 Jun;132:269-77.
8
A method for the fluorimetric determination of adrenaline and noradrenaline in tissues.一种用于荧光测定组织中肾上腺素和去甲肾上腺素的方法。
Acta Physiol Scand. 1958 Dec 15;44(3-4):273-92. doi: 10.1111/j.1748-1716.1958.tb01627.x.
9
Catecholamine metabolism in experimental hypertension in the rat.
Circ Res. 1967 Jan;20(1):136-45. doi: 10.1161/01.res.20.1.136.
10
A reduction in the accumulation of H3-norepinephrine in experimental hypertension.
Life Sci. 1966 Dec;5(24):2283-91. doi: 10.1016/0024-3205(66)90064-6.
Zotero 插件