中枢肾上腺素能神经元在兔肾性高血压中的重要性。
The importance of central adrenergic neurones in renal hypertension in rabbits.
作者信息
Chalmers J P, Dollery C T, Lewis P J, Reid J L
出版信息
J Physiol. 1974 Apr;238(2):403-11. doi: 10.1113/jphysiol.1974.sp010532.
Abstract
- Central nervous system adrenergic neurones were partially destroyed by injection of 6-hydroxydopamine (6-OHD) into the cisterna magna of normal rabbits and of rabbits with renal hypertension produced by bilateral wrapping of the kidneys with cellophane.2. Six weeks after renal manipulation, the mean arterial pressure of control animals was 122.1 +/- 2.4 mmHg while the pressure of rabbits which had been pre-treated with intracisternal 6-OHD was only 100.0 +/- 4.3 mmHg.3. Partial destruction of central adrenergic neurones by injection of 6-OHD into the cisterna magna produced a sustained lowering of arterial pressure in rabbits with established renal hypertension, whether this hypertension had been short (6 weeks) or of long duration (18 weeks).4. Adrenergic neurones in the central nervous system play a role in the development and maintenance of the raised arterial pressure in rabbits with renal hypertension.
摘要
通过向正常家兔以及用玻璃纸双侧包裹肾脏所致肾性高血压家兔的小脑延髓池注射6-羟基多巴胺（6-OHD），部分破坏中枢神经系统的肾上腺素能神经元。
肾脏手术六周后，对照动物的平均动脉压为122.1±2.4 mmHg，而预先经小脑延髓池注射6-OHD的家兔血压仅为100.0±4.3 mmHg。
向小脑延髓池注射6-OHD对中枢肾上腺素能神经元的部分破坏，可使已形成肾性高血压的家兔动脉压持续降低，无论该高血压是短期（6周）还是长期（18周）形成的。
中枢神经系统中的肾上腺素能神经元在肾性高血压家兔动脉压升高的发生和维持中起作用。
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