Wanner A, Mezey R J, Reinhart M E, Eyre P
J Appl Physiol Respir Environ Exerc Physiol. 1979 Nov;47(5):917-22. doi: 10.1152/jappl.1979.47.5.917.
In 10 conscious ewes with cutaneous sensitivity to Ascaris suum, measurements of pulmonary resistance (RL), static lung compliance (Cst), functional residual capacity (FRC), and arterial blood gas composition along with arterial plasma histamine concentration (H) were obtained before and after inhalation challenge with A. suum extract. Five animals showed no changes in respiratory mechanics after A. suum challenge; in these H did not change. The remaining five animals responded to A. suum challenge with bronchospasm reflected by the following maximum changes in mean values that were significant 15 and 30 min after beginning of challenge, respectively: RL 248% , FRC 126%, specific pulmonary conductance 33%, and arterial PO2 63% of base line. These parameters returned towards base line by 120 min. No changes occurred in Cst, arterial PCO2, and pH. Five minutes after beginning of A. suum challenge, mean H was increased to 423% of base line with a return to base line 10 min later. In the same 5 animals, no changes were observed in pulmonary function or H after inhalation of ragweed extract (control). These results suggest that antigen-induced bronchospasm in sensitized conscious sheep represents an anaphylactic airway response and shares distinct physiological features with human bronchial asthma including pulmonary hyperinflation.
在10只对猪蛔虫具有皮肤敏感性的清醒母羊中，在吸入猪蛔虫提取物激发前后，分别测量了肺阻力（RL）、静态肺顺应性（Cst）、功能残气量（FRC）、动脉血气成分以及动脉血浆组胺浓度（H）。5只动物在猪蛔虫激发后呼吸力学未发生变化；这些动物的H也未改变。其余5只动物对猪蛔虫激发产生了支气管痉挛反应，分别在激发开始后15分钟和30分钟时，平均值出现以下最大变化且具有统计学意义：RL为基线值的248%，FRC为基线值的126%，比肺传导率为基线值的33%，动脉血氧分压为基线值的63%。这些参数在120分钟时恢复至基线水平。Cst、动脉血二氧化碳分压和pH值未发生变化。猪蛔虫激发开始后5分钟，平均H增加至基线值的423%，10分钟后恢复至基线水平。在相同的5只动物中，吸入豚草提取物（对照）后，肺功能和H未观察到变化。这些结果表明，致敏清醒绵羊中抗原诱导的支气管痉挛代表一种过敏气道反应，并且与人类支气管哮喘具有包括肺过度充气在内的独特生理特征。
