Allegra L, Abraham W M, Chapman G A, Wanner A
J Appl Physiol Respir Environ Exerc Physiol. 1983 Sep;55(3):726-30. doi: 10.1152/jappl.1983.55.3.726.
Antigen-induced bronchospasm is associated with an impairment of airway mucociliary clearance, but the duration of this defect has not been examined. In the present study, we determined the time course of mucociliary dysfunction following inhalation challenge with Ascaris suum extract in conscious sheep with hypersensitivity to this antigen. Tracheal mucous velocity (TMV) as an index of mucociliary function, pulmonary resistance (RL), and arterial oxygen tension (Pao2) were measured prior to, immediately after, and serially for 8 h after inhalation challenge. TMV and Pao2 were then measured periodically for at least 2 wk. Immediately after A. suum challenge, mean RL increased to 264% of base line (P less than 0.05), and mean Pao2 decreased to 61% of base line (P less than 0.05). By 2 h postchallenge, mean RL and Pao2 had returned to base line but mean TMV had fallen to 61% of base line (P less than 0.05). Mean TMV reached a minimum of 35% of base line after 5 h (P less than 0.05) and remained significantly depressed between 37% and 54% of base line for 7 days; by day 9, mean TMV had returned to base line. Inhalation challenge with a control antigen (ragweed) failed to alter mean TMV, RL, and Pao2 during the first 8 h and TMV and Pao2 at any time throughout the 2-wk observation period.(ABSTRACT TRUNCATED AT 250 WORDS)
抗原诱导的支气管痉挛与气道黏液纤毛清除功能受损有关，但这种缺陷的持续时间尚未得到研究。在本研究中，我们测定了对猪蛔虫提取物过敏的清醒绵羊吸入该抗原激发后黏液纤毛功能障碍的时间进程。在吸入激发前、激发后即刻以及激发后连续8小时测量气管黏液速度（TMV）作为黏液纤毛功能的指标、肺阻力（RL）和动脉血氧分压（Pao2）。然后在至少2周内定期测量TMV和Pao2。猪蛔虫激发后即刻，平均RL增加至基线的264%（P<0.05），平均Pao2降至基线的61%（P<0.05）。激发后2小时，平均RL和Pao2恢复至基线，但平均TMV降至基线的61%（P<0.05）。5小时后平均TMV降至基线的35%（P<0.05），并在7天内显著低于基线的37%至54%；到第9天，平均TMV恢复至基线。用对照抗原（豚草）进行吸入激发在最初8小时内未改变平均TMV、RL和Pao2，在整个2周观察期内任何时候也未改变TMV和Pao2。（摘要截短于250字）
