Treatment of metastatic granulosa cell tumor in a dog.

A 10-year-old female dog with endocrine abnormalities and abdominal distention was found to have a functional ovarian tumor. Exploratory laparotomy and histologic examination of excised specimens led to a diagnosis of granulosa cell tumor with widespread metastasis. The prognosis appeared grave because tumor tissue remained on the liver and parietal peritoneum. An immunotherapeutic regimen was instituted and was continued for 4 months. The dog appeared to be free of disease on periodic examinations and continued to do well 2 years after diagnosis and surgery.