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维生素A代谢的研究。维生素A状态对某些类固醇分泌率进入妊娠大鼠卵巢静脉血的影响。

Studies on metabolism of vitamin A. The effect of vitamin A status on the secretion rates of some steroids into the ovarian venous blood of pregnant rats.

作者信息

Ganguly J, Pope G S, Thompson S Y, Toothill J, Edwards-Webb J D, Waynforth H B

出版信息

Biochem J. 1971 Apr;122(2):235-9. doi: 10.1042/bj1220235.

DOI:10.1042/bj1220235
PMID:5117569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1176767/
Abstract
  1. Rats raised on a vitamin A-deficient diet supplemented with either retinyl acetate or retinoic acid were mated and became pregnant. 2. The rates of secretion of progesterone, 20alpha-hydroxypregn-4-en-3-one, oestradiol-17beta and oestrone into the ovarian-venous blood of rats in these two groups were measured on days 9 and 15 of pregnancy. 3. Rates of secretion of progesterone and 20alpha-hydroxypregn-4-en-3-one, both on days 9 and 15, were lower for the rats given retinoic acid. No such differences were found in ovarian oestrogen secretion. 4. The implications of these results are discussed in the light of the previous demonstration that the activity of ovarian 3beta-hydroxy-Delta(5)-steroid dehydrogenase was markedly less in pregnant rats given retinoic acid.
摘要
  1. 用醋酸视黄酯或视黄酸补充维生素A缺乏饮食饲养的大鼠进行交配并怀孕。2. 在怀孕第9天和第15天,测量这两组大鼠卵巢静脉血中孕酮、20α-羟基孕-4-烯-3-酮、雌二醇-17β和雌酮的分泌率。3. 给予视黄酸的大鼠在怀孕第9天和第15天的孕酮和20α-羟基孕-4-烯-3-酮分泌率均较低。卵巢雌激素分泌未发现此类差异。4. 根据先前的证明,即给予视黄酸的怀孕大鼠卵巢3β-羟基-Δ(5)-类固醇脱氢酶的活性明显较低,对这些结果的意义进行了讨论。

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1
Studies on metabolism of vitamin A. The effect of vitamin A status on the secretion rates of some steroids into the ovarian venous blood of pregnant rats.维生素A代谢的研究。维生素A状态对某些类固醇分泌率进入妊娠大鼠卵巢静脉血的影响。
Biochem J. 1971 Apr;122(2):235-9. doi: 10.1042/bj1220235.
2
Effect of vitamin A status on the content of some steroids in the ovarian-vein blood of pregnant rats.维生素A状态对妊娠大鼠卵巢静脉血中某些类固醇含量的影响。
Biochem J. 1971 Jan;121(1):22P. doi: 10.1042/bj1210022p.
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The roles of pregn-5-ene-3 beta, 20 alpha-diol and 20 alpha-hydroxy steroid dehydrogenase in the control of progesterone synthesis preceding parturition and lactogenesis in the rat.孕-5-烯-3β,20α-二醇和20α-羟基类固醇脱氢酶在大鼠分娩和泌乳前孕酮合成调控中的作用。
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Studies on metabolism of vitamin A. The effect of hormones on gestation in retinoate-fed female rats.维生素A代谢研究。激素对喂食视黄酸的雌性大鼠妊娠的影响。
Biochem J. 1969 Jan;111(1):97-105. doi: 10.1042/bj1110097.
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Ovarian secretion of progesterone and 20alpha-hydroxypregn-4-en-3-one during rat estrous cycle in chronological relation to pituitary release of luteinizing hormone.大鼠发情周期中卵巢孕酮和20α-羟基孕-4-烯-3-酮的分泌与垂体促黄体生成素释放的时间关系。
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A proposed sequence of hormones controlling the induction of luteal 20alpha-hydroxy steroid dehydrogenase and progesterone withdrawal in the late-pregnant rat.一种关于控制妊娠后期大鼠黄体20α-羟基类固醇脱氢酶诱导和孕酮撤退的激素作用序列假说。
Biochem J. 1976 Dec 15;160(3):663-70. doi: 10.1042/bj1600663.

引用本文的文献

1
Studies on the metabolism of vitamin A: the effect of vitamin A status on the content of some steroids in the ovaries of pregnant rats.维生素A代谢的研究:维生素A状态对妊娠大鼠卵巢中某些类固醇含量的影响。
Biochem J. 1971 Jul;123(4):669-70. doi: 10.1042/bj1230669.
2
Effect of vitamin A deprivation on the cholesterol side-chain cleavage enzyme activity of testes and ovaries of rats.维生素A缺乏对大鼠睾丸和卵巢胆固醇侧链裂解酶活性的影响。
Biochem J. 1973 Sep;136(1):221-3. doi: 10.1042/bj1360221.
3
Effect of vitamin A nutritional status on the ribonucleic acids of liver, intestinal mucosa and testes of rats.维生素A营养状况对大鼠肝脏、肠黏膜及睾丸核糖核酸的影响。
Biochem J. 1977 Sep 15;166(3):339-46. doi: 10.1042/bj1660339.

本文引用的文献

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Thin-layer chromatography of plasma lipids by single development.通过单次展开进行血浆脂质的薄层色谱分析。
Lipids. 1967 Nov;2(6):501-2. doi: 10.1007/BF02533180.
2
Methods of paper chromatography of steroids applicable to the study of steroids in mammalian blood and tissues.适用于研究哺乳动物血液和组织中类固醇的类固醇纸色谱法。
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The use of 2-3-5-triphenyltetrazolium chloride in the biological assay of oestrogens.
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AN APPROACH TO THE SYSTEMATIC ANALYSIS OF URINARY STEROIDS.一种尿甾体系统分析方法
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FURTHER STUDIES ON THE USE OF TETRAZOLIUM IN THE BIOLOGICAL ASSAY OF OESTROGENS.
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VITAMIN A AND REPRODUCTION IN RATS.维生素A与大鼠繁殖
Proc R Soc Lond B Biol Sci. 1964 Feb 18;159:510-35. doi: 10.1098/rspb.1964.0017.
7
Studies on metabolism of vitamin A. 1. The biological activity of vitamin A acid in rats.维生素A代谢的研究。1. 视黄酸在大鼠体内的生物活性。
Biochem J. 1963 May;87(2):305-11. doi: 10.1042/bj0870305.
8
Some observations on the biological assay of vitamin A and its precursors by the vaginal-smear method.
Br J Nutr. 1957;11(2):173-84. doi: 10.1079/bjn19570034.
9
Ovarian secretion of progesterone and 20-alpha-hydroxypregn-4-en-3-one during pseudopregnancy and pregnancy in rats.大鼠假孕和妊娠期间卵巢孕酮及20-α-羟基孕-4-烯-3-酮的分泌
Endocrinology. 1967 Sep;81(3):617-22. doi: 10.1210/endo-81-3-617.
10
The effect of vitamin A deficiency on the biosynthesis of steroid hormones in rats.维生素A缺乏对大鼠甾体激素生物合成的影响。
Biochem J. 1966 Apr;99(1):138-45. doi: 10.1042/bj0990138.