维生素A代谢的研究。维生素A状态对某些类固醇分泌率进入妊娠大鼠卵巢静脉血的影响。
Studies on metabolism of vitamin A. The effect of vitamin A status on the secretion rates of some steroids into the ovarian venous blood of pregnant rats.
作者信息
Ganguly J, Pope G S, Thompson S Y, Toothill J, Edwards-Webb J D, Waynforth H B
出版信息
Biochem J. 1971 Apr;122(2):235-9. doi: 10.1042/bj1220235.
Abstract
- Rats raised on a vitamin A-deficient diet supplemented with either retinyl acetate or retinoic acid were mated and became pregnant. 2. The rates of secretion of progesterone, 20alpha-hydroxypregn-4-en-3-one, oestradiol-17beta and oestrone into the ovarian-venous blood of rats in these two groups were measured on days 9 and 15 of pregnancy. 3. Rates of secretion of progesterone and 20alpha-hydroxypregn-4-en-3-one, both on days 9 and 15, were lower for the rats given retinoic acid. No such differences were found in ovarian oestrogen secretion. 4. The implications of these results are discussed in the light of the previous demonstration that the activity of ovarian 3beta-hydroxy-Delta(5)-steroid dehydrogenase was markedly less in pregnant rats given retinoic acid.
摘要
- 用醋酸视黄酯或视黄酸补充维生素A缺乏饮食饲养的大鼠进行交配并怀孕。2. 在怀孕第9天和第15天，测量这两组大鼠卵巢静脉血中孕酮、20α-羟基孕-4-烯-3-酮、雌二醇-17β和雌酮的分泌率。3. 给予视黄酸的大鼠在怀孕第9天和第15天的孕酮和20α-羟基孕-4-烯-3-酮分泌率均较低。卵巢雌激素分泌未发现此类差异。4. 根据先前的证明，即给予视黄酸的怀孕大鼠卵巢3β-羟基-Δ(5)-类固醇脱氢酶的活性明显较低，对这些结果的意义进行了讨论。
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Studies on metabolism of vitamin A. The effect of vitamin A status on the secretion rates of some steroids into the ovarian venous blood of pregnant rats.维生素A代谢的研究。维生素A状态对某些类固醇分泌率进入妊娠大鼠卵巢静脉血的影响。
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Studies on the metabolism of vitamin A: the effect of vitamin A status on the content of some steroids in the ovaries of pregnant rats.维生素A代谢的研究：维生素A状态对妊娠大鼠卵巢中某些类固醇含量的影响。
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