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维生素A缺乏对大鼠睾丸和卵巢胆固醇侧链裂解酶活性的影响。

Effect of vitamin A deprivation on the cholesterol side-chain cleavage enzyme activity of testes and ovaries of rats.

作者信息

Jayaram M, Murthy S K, Ganguly J

出版信息

Biochem J. 1973 Sep;136(1):221-3. doi: 10.1042/bj1360221.

DOI:10.1042/bj1360221
PMID:4772624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1165941/
Abstract

The cholesterol side-chain cleavage enzyme activity is decreased considerably at the mild stage of vitamin A deficiency in rat testes and ovaries and the decrease in activity becomes more pronounced with progress of deficiency. Supplementation of the deficient rats with retinyl acetate, but not retinoic acid, restores the enzyme activity to normal values. The cholesterol side-chain cleavage enzyme of adrenals is not affected by any of the above treatments.

摘要

在维生素A缺乏的轻度阶段，大鼠睾丸和卵巢中的胆固醇侧链裂解酶活性显著降低，且随着缺乏程度的加重，活性降低变得更加明显。给缺乏维生素A的大鼠补充醋酸视黄酯而非视黄酸，可使该酶活性恢复至正常水平。肾上腺的胆固醇侧链裂解酶不受上述任何处理的影响。

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Biochem J. 1973 Sep;136(1):221-3. doi: 10.1042/bj1360221.
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Effect of vitamin A nutritional status on the ribonucleic acids of liver, intestinal mucosa and testes of rats.维生素A营养状况对大鼠肝脏、肠黏膜及睾丸核糖核酸的影响。
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本文引用的文献

1
VITAMIN A AND REPRODUCTION IN RATS.维生素A与大鼠繁殖
Proc R Soc Lond B Biol Sci. 1964 Feb 18;159:510-35. doi: 10.1098/rspb.1964.0017.
2
Studies on metabolism of vitamin A. 1. The biological activity of vitamin A acid in rats.维生素A代谢的研究。1. 视黄酸在大鼠体内的生物活性。
Biochem J. 1963 May;87(2):305-11. doi: 10.1042/bj0870305.
3
The effect of vitamin A deficiency on the biosynthesis of steroid hormones in rats.维生素A缺乏对大鼠甾体激素生物合成的影响。
Biochem J. 1966 Apr;99(1):138-45. doi: 10.1042/bj0990138.
4
Studies on metabolism of vitamin A. The effect of hormones on gestation in retinoate-fed female rats.维生素A代谢研究。激素对喂食视黄酸的雌性大鼠妊娠的影响。
Biochem J. 1969 Jan;111(1):97-105. doi: 10.1042/bj1110097.
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Studies on the metabolism of vitamin A: the effect of vitamin A status on the content of some steroids in the ovaries of pregnant rats.维生素A代谢的研究：维生素A状态对妊娠大鼠卵巢中某些类固醇含量的影响。
Biochem J. 1971 Jul;123(4):669-70. doi: 10.1042/bj1230669.
6
Studies on metabolism of vitamin A. The effect of vitamin A status on the secretion rates of some steroids into the ovarian venous blood of pregnant rats.维生素A代谢的研究。维生素A状态对某些类固醇分泌率进入妊娠大鼠卵巢静脉血的影响。
Biochem J. 1971 Apr;122(2):235-9. doi: 10.1042/bj1220235.
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On the pathophysiology of vitamin A deficiency.
Nutr Rev. 1971 Jan;29(1):3-6. doi: 10.1111/j.1753-4887.1971.tb07206.x.
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Biosynthesis of pregnenolone.
Recent Prog Horm Res. 1971;27:303-49. doi: 10.1016/b978-0-12-571127-2.50032-8.
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Cerebrospinal fluid pressure, growth, and hematology in relation to retinal status of the rat in acute vitamin A deficiency.急性维生素A缺乏大鼠的脑脊液压力、生长及血液学与视网膜状态的关系
J Nutr. 1972 Dec;102(12):1585-93. doi: 10.1093/jn/102.12.1585.
10
Reexamination of enzyme activities thought to show evidence of a coenzyme role for vitamin A.对被认为显示维生素A具有辅酶作用证据的酶活性进行重新检查。
Am J Clin Nutr. 1969 Aug;22(8):1003-13. doi: 10.1093/ajcn/22.8.1003.