δ-霉素，新型大环内酯类抗生素。III. 化学结构。

Deltamycins, new macrolide antibiotics. III. Chemical structures.

作者信息

Shimauchi Y, Kubo K, Osumi K, Okamura K, Fukagawa Y, Ishikura T, Lein J

出版信息

J Antibiot (Tokyo). 1979 Sep;32(9):878-83. doi: 10.7164/antibiotics.32.878.

DOI:10.7164/antibiotics.32.878

Abstract

The structures of deltamycins A1,A2,A3 and A4 belonging to the basic macrolide family of antibiotics were determined mainly from their spectral properties. Deltamycin A4 was identified as carbomycin A having an isovaleryl group on the mycarose moiety of the molecule. Deltamycin A1,A2 and A3 possess similarities to the structure of deltamycin A4, but they have acetyl, propionyl and n-butyryl group, respectively, in the place of isovaleryl group of deltamycin A4. These structures were confirmed by chemical synthesis from deltamycin X (4''-O-deacyldeltamycin) and the corresponding acyl chlorides.

摘要

属于基本大环内酯类抗生素家族的δ霉素A1、A2、A3和A4的结构主要通过其光谱性质确定。δ霉素A4被鉴定为在分子的霉糖部分具有异戊酰基的碳霉素A。δ霉素A1、A2和A3与δ霉素A4的结构相似，但它们分别在δ霉素A4的异戊酰基位置具有乙酰基、丙酰基和正丁酰基。这些结构通过从δ霉素X（4''-O-脱酰基δ霉素）和相应的酰氯进行化学合成得到了证实。