抗生素的微生物转化 II. 马立霉素III的其他转化产物

Microbial transformation of antibiotics II. Additional transformation products of maridomycin III.

作者信息

Shibata M, Uyeda M, Mori S

出版信息

J Antibiot (Tokyo). 1976 Aug;29(8):824-8. doi: 10.7164/antibiotics.29.824.

DOI:10.7164/antibiotics.29.824

Abstract

Streptomyces sp. strain No. K-245 was found to transform maridomycin III into four derivatives (A1, A2, A3 and A4) in addition to the transformation products reported previously. Isolation of the main product A1 was carried out by column chromatography on silica gel developed with CHCl3-MeOH (19:1). From the partial investigation of the structure of A1, it proved to have a C-18-aldehyde group and C 4''-propionyl group but no antimicrobial activity. The relationships between A group's derivatives and known derivatives of maridomycin III are also discussed.

摘要

链霉菌属菌株No. K - 245被发现除了能产生先前报道的转化产物外，还能将马立霉素III转化为四种衍生物（A1、A2、A3和A4）。主要产物A1通过在以CHCl3 - MeOH（19:1）展开的硅胶柱色谱上进行分离。通过对A1结构的部分研究，证明它含有一个C - 18 - 醛基和一个C 4'' - 丙酰基，但没有抗菌活性。文中还讨论了A组衍生物与马立霉素III已知衍生物之间的关系。