沃尔曼病血片中酶缺乏的组织化学检测。
Histochemical detection of the enzyme deficiency in blood films in Wolman's disease.
作者信息
Lake B D
出版信息
J Clin Pathol. 1971 Oct;24(7):617-20. doi: 10.1136/jcp.24.7.617.
Abstract
The clinical diagnosis of Wolman's disease (acid esterase deficiency) can be confirmed by a histochemical staining method using blood films. Acid esterase activity is found normally in lymphocytes, but in Wolman's disease only a very low level of activity can be detected. An intermediate level of activity was demonstrated in heterozygotes. The method may also be applicable in the prenatal detection of the disease.
摘要
沃尔曼病（酸性酯酶缺乏症）的临床诊断可通过使用血涂片的组织化学染色方法来确诊。正常情况下在淋巴细胞中可发现酸性酯酶活性，但在沃尔曼病中只能检测到极低水平的活性。在杂合子中显示出中等水平的活性。该方法也可能适用于该疾病的产前检测。
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