Klempman S, Miller K
Br J Exp Pathol. 1977 Oct;58(5):557-64.
The histological changes in the regional thoracic lymph nodes of rats exposed to silica dust by inhalation are recorded. A dual response is noted involving both inflammatory and immune mechanisms, resulting in a fibroblastic connective tissue reaction and a plasma-cell-macrophage interaction. It is proposed that the progressive silicotic lesions obstruct the lymphatic channels in the lymph nodes, thus interfering with the lymph drainage from the lung and aggravating the silicotic process in the lung itself.
记录了通过吸入二氧化硅粉尘暴露的大鼠区域胸段淋巴结的组织学变化。观察到一种双重反应，涉及炎症和免疫机制，导致成纤维细胞结缔组织反应和浆细胞 - 巨噬细胞相互作用。有人提出，进行性硅沉着病病变阻塞淋巴结中的淋巴管，从而干扰肺的淋巴引流并加重肺本身的硅沉着病进程。
