莰二醇的代谢
Metabolism of camphanediols.
作者信息
Robertson J S, Solomon E
出版信息
Biochem J. 1971 Feb;121(3):503-9. doi: 10.1042/bj1210503.
Abstract
- The metabolism of the camphane-2,3-diols and camphane was investigated in rabbits. All the compounds increased the content of glucuronide in the urine. 2. Both trans- and cis-diols gave rise to ketols; the cis-diols gave rise to trans-diols, but not vice versa; camphorquinone gave cis-diol, ketols and trans-diol; camphane did not give rise to diols. 3. The possibility is discussed that an enediol is the intermediate for ketol interconversions in the present series of compounds and in other series such as hydroxyoestrones and hydroxyindanones.
摘要
- 研究了莰烷-2,3-二醇和莰烷在兔子体内的代谢情况。所有这些化合物都增加了尿液中葡糖醛酸苷的含量。2. 反式二醇和顺式二醇都会生成酮醇；顺式二醇会生成反式二醇，但反式二醇不会生成顺式二醇；樟脑醌会生成顺式二醇、酮醇和反式二醇；莰烷不会生成二醇。3. 讨论了在本系列化合物以及其他系列化合物（如羟基雌酮和羟基茚满酮）中，烯二醇作为酮醇相互转化中间体的可能性。
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