β-紫罗兰酮的代谢。家兔尿液中代谢产物的分离、表征与鉴定。
Metabolism of beta-ionone. Isolation, characterization and identification of the metabolitesin the urine of rabbits.
作者信息
Ide H, Toki S
出版信息
Biochem J. 1970 Sep;119(2):281-7. doi: 10.1042/bj1190281.
Abstract
- Rabbits dosed orally with beta-ionone excreted in the urine unchanged beta-ionone, 3-oxo-beta-ionone, 3-oxo-beta-ionol, dihydro-3-oxo-beta-ionol and 3-hydroxy-beta-ionol. 2. Excretion products were isolated as 2,4-dinitrophenylhydrazone derivatives (beta-ionone, 3-oxo-beta-ionone, 3-oxo-beta-ionol and dihydro-3-oxo-beta-ionol) and as p-nitrobenzoate derivatives (3-oxo-beta-ionol, dihydro-3-oxo-beta-ionol and 3-hydroxy-beta-ionol), which were characterized and identified by comparison with the synthetic authentic compounds. 3. The glucuronides of 3-oxo-beta-ionol and dihydro-3-oxo-beta-ionol were also detected in the urine. The latter compound was isolated as free glucuronide, sodium salt and 2,4-dinitrophenylhydrazone.
摘要
- 经口给予β-紫罗兰酮的兔子，其尿液中排泄出未变化的β-紫罗兰酮、3-氧代-β-紫罗兰酮、3-氧代-β-紫罗兰醇、二氢-3-氧代-β-紫罗兰醇和3-羟基-β-紫罗兰醇。2. 排泄产物被分离为2,4-二硝基苯腙衍生物（β-紫罗兰酮、3-氧代-β-紫罗兰酮、3-氧代-β-紫罗兰醇和二氢-3-氧代-β-紫罗兰醇）和对硝基苯甲酸酯衍生物（3-氧代-β-紫罗兰醇、二氢-3-氧代-β-紫罗兰醇和3-羟基-β-紫罗兰醇），通过与合成的标准化合物比较对其进行了表征和鉴定。3. 在尿液中还检测到了3-氧代-β-紫罗兰醇和二氢-3-氧代-β-紫罗兰醇的葡萄糖醛酸苷。后一种化合物被分离为游离葡萄糖醛酸苷、钠盐和2,4-二硝基苯腙。
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