Aurelian L, Strandberg J D, Melendez L V, Johnson L A
Science. 1971 Nov 12;174(4010):704-7. doi: 10.1126/science.174.4010.704.
A herpesvirus has been isolated from spontaneously degenerating cultures of cervical tumor cells grown in vitro. The virus was identified as a type 2 herpesvirus on the basis of biologic properties, including plaque morphology and microtubule formation in infected HEp-2 cells, and of immunologic specificity as determined by neutralization. Herpesvirus antigens and virus particles were not seen in duplicate cultures of viable cervical tumor cells.
从体外培养的自发退化的宫颈肿瘤细胞中分离出一种疱疹病毒。根据生物学特性，包括在感染的HEp-2细胞中的噬斑形态和微管形成，以及通过中和试验确定的免疫特异性，该病毒被鉴定为2型疱疹病毒。在存活的宫颈肿瘤细胞的重复培养物中未观察到疱疹病毒抗原和病毒颗粒。
