1型和2型活单纯疱疹病毒对培养的哺乳动物细胞的转化
Transformation of cultured mammalian cells by viable herpes simplex virus subtypes 1 and 2.
作者信息
Garfinkle B, McAuslan B R
出版信息
Proc Natl Acad Sci U S A. 1974 Jan;71(1):220-4. doi: 10.1073/pnas.71.1.220.
Abstract
A continuous line of rodent cells carrying the genome of the Rous sarcoma virus was stably transformed by exposure to viable herpes simplex virus of either subtype 1 or 2. Transformation was accompanied by alteration of morphology, growth characteristics, acquisition of a thymidine kinase activity (EC 2.7.1.21) resembling the corresponding specific activity of the enzyme in the herpes simplex virus, and capacity to express continuously some antigens specific for herpes simplex virus.
摘要
通过暴露于1型或2型活单纯疱疹病毒，携带劳氏肉瘤病毒基因组的连续传代啮齿动物细胞系被稳定转化。转化伴随着形态学改变、生长特性改变、获得类似于单纯疱疹病毒中该酶相应比活性的胸苷激酶活性（EC 2.7.1.21），以及持续表达一些单纯疱疹病毒特异性抗原的能力。
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