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通过口腔接触污染物经唾液介导传播乙型病毒性肝炎的潜在风险。

Potential risk of salivary-mediated viral hepatitis type B transmission from oral exposure to fomites.

作者信息

Osterholm M T, Max B J, Hanson M, Polesky H F

出版信息

J Hyg (Lond). 1979 Dec;83(3):487-90. doi: 10.1017/s0022172400026322.

Abstract

Twelve grade school and junior high school students had oral exposures to hepatitis B surface antigen (HBsAg) positive saliva via contact with contaminated musical instruments. The 12 exposed students and 18 students who served as age and sex matched controls were tested for the presence of HBsAg and antibody to the hepatitis surface antigen (anti-HBs) at 2 weeks, 8 weeks and 6 months after exposure. All students were negative for HBsAg and anti-HBs on all dates tested and reported no illness during that time suggestive of viral hepatitis. There was no evidence of viral hepatitis, type B transmission from the exposure. The students probably experienced the maximum possible oral exposure from direct or fomites contact, since there was no cleaning of the musical instruments between use by the students and teacher. Based on these results, the risk of transmission of viral hepatitis, type B from oral contact with fomites is unlikely.

摘要

12名小学生和初中生通过接触受污染的乐器而经口接触了乙型肝炎表面抗原(HBsAg)阳性唾液。在接触后的2周、8周和6个月,对这12名暴露学生以及18名年龄和性别匹配的对照学生进行了HBsAg和乙型肝炎表面抗原抗体(抗-HBs)检测。所有学生在所有检测日期的HBsAg和抗-HBs均为阴性,且在此期间均未报告提示病毒性肝炎的疾病。没有证据表明此次暴露导致了乙型病毒性肝炎传播。由于学生和教师使用乐器期间未进行清洁,这些学生可能经历了来自直接接触或通过污染物接触的最大可能经口暴露。基于这些结果,经口接触污染物传播乙型病毒性肝炎的风险不大。

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Hepatitis B antigen in saliva and mouth washings.唾液和漱口液中的乙型肝炎抗原。
Lancet. 1972 Oct 7;2(7780):726-7. doi: 10.1016/s0140-6736(72)92021-1.
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Hepatitis B antigen in saliva, urine, and stool.唾液、尿液和粪便中的乙型肝炎抗原。
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