Thijs J C, van Bergeijk L, Heijtink R A, Douwes A C, Meuwissen S G
Hepatogastroenterology. 1984 Apr;31(2):69-71.
A family is described, of whom all members were found to be infected with the adw2 subtype hepatitis B virus. The mother and both the children were positive for anti-HBs (anti-y). The usual explanation for the co-occurrence of HBsAg and anti-HBs ("two infections hypothesis") was clinically highly unlikely. HLA typing was performed to investigate the possibility that genetically determined host dependent factors are involved. However, no relationship between the simultaneous presence of HBsAg and anti-HBs and a particular haplotype was observed.
描述了一个家庭，其所有成员均被发现感染了乙肝病毒adw2亚型。母亲和两个孩子的抗-HBs（抗-y）均呈阳性。对于HBsAg和抗-HBs同时出现（“双重感染假说”）的常见解释在临床上极不可能。进行了HLA分型以研究是否涉及基因决定的宿主相关因素。然而，未观察到HBsAg和抗-HBs同时存在与特定单倍型之间的关系。
