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Kinetic studies of the N-demethylation of ethylmorphine by a cytochrome P-450-dependent enzyme system in human liver microsomes.人肝微粒体中细胞色素P-450依赖酶系统对乙基吗啡N-去甲基化的动力学研究。
Biochem J. 1971 Mar;122(1):30P. doi: 10.1042/bj1220030pa.
2
Effect of temperature on the relationship between hepatic microsomal cytochrome P-450 reduction and ethylmorphine demethylation.
Pharmacology. 1971;5(5):295-300. doi: 10.1159/000136202.
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Species and sex differences in electron transport systems in liver microsomes and their relationship to ethylmorphine demethylation.肝微粒体中电子传递系统的物种和性别差异及其与乙基吗啡去甲基化的关系。
Life Sci. 1969 Jan 15;8(2):85-91. doi: 10.1016/0024-3205(69)90121-0.
4
Mechanism of hepatic drug oxidation and its relationship to individual differences in rates of oxidation in man.肝脏药物氧化机制及其与人氧化速率个体差异的关系。
Ann N Y Acad Sci. 1971 Jul 6;179:411-20. doi: 10.1111/j.1749-6632.1971.tb46918.x.
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The binding of metyrapone to cytochrome P-450 and its inhibitory action on liver microsomal mixed-function oxidase reactions.甲吡酮与细胞色素P - 450的结合及其对肝微粒体混合功能氧化酶反应的抑制作用。
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The kinetics of ethylmorphine activation of the NADPH-cytochrome P-450 reductase activity of hepatic microsomes from male and female rats.雄性和雌性大鼠肝脏微粒体中NADPH-细胞色素P-450还原酶活性的乙基吗啡激活动力学。
Chem Biol Interact. 1971 Aug;3(4):279-81. doi: 10.1016/0009-2797(71)90060-3.
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Effect of adrenalectomy and cortisone administration on components of the liver microsomal mixed function oxygenase system of male rats which catalyzes ethylmorphine metabolism.肾上腺切除术及给予可的松对催化乙基吗啡代谢的雄性大鼠肝脏微粒体混合功能氧化酶系统各组分的影响。
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Studies of the stoichiometric relationships between the oxidation of drugs and the oxidation of reduced pyridine nucleotides by liver microsomal enzymes.
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Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes.小鼠肝脏微粒体细胞色素P450酶对二氢吗啡的N-去甲基化作用。
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引用本文的文献

1
Determination of drug metabolizing enzymes in needle biopsies of human liver.人肝脏穿刺活检中药物代谢酶的测定
Eur J Clin Pharmacol. 1972 Mar;4(2):65-73. doi: 10.1007/BF00562499.
2
Drug absorption in gastrointestinal disease with particular reference to malabsorption syndromes.胃肠道疾病中的药物吸收，特别涉及吸收不良综合征。
Clin Pharmacokinet. 1977 Jan-Feb;2(1):45-60. doi: 10.2165/00003088-197702010-00004.

本文引用的文献

1
Sex differences in the kinetic constants for the N-demethylation of ethylmorphine by rat liver microsomes.大鼠肝脏微粒体对乙基吗啡N-去甲基化反应动力学常数的性别差异。
Biochem Pharmacol. 1968 Sep;17(9):1865-72. doi: 10.1016/0006-2952(68)90102-0.
2
Species and sex differences in electron transport systems in liver microsomes and their relationship to ethylmorphine demethylation.肝微粒体中电子传递系统的物种和性别差异及其与乙基吗啡去甲基化的关系。
Life Sci. 1969 Jan 15;8(2):85-91. doi: 10.1016/0024-3205(69)90121-0.
3
[The activity of N- and O-demethylase in the human liver].
Biochem Pharmacol. 1970 Feb;19(2):327-42. doi: 10.1016/0006-2952(70)90190-5.
4
Cytochrome P-450 and drug oxidation.细胞色素P - 450与药物氧化
Biochem J. 1969 Dec;115(5):23P-24P. doi: 10.1042/bj1150023p.
5
Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.
Mol Pharmacol. 1969 Mar;5(2):109-22.
6
Cytochromes P-450 and b5 in human liver microsomes.
Clin Pharmacol Ther. 1969 Sep-Oct;10(5):655-9. doi: 10.1002/cpt1969105655.

Kinetic studies of the N-demethylation of ethylmorphine by a cytochrome P-450-dependent enzyme system in human liver microsomes.

作者信息

Thorgeirsson S S, Davies D S

出版信息

Biochem J. 1971 Mar;122(1):30P. doi: 10.1042/bj1220030pa.

DOI:10.1042/bj1220030pa
PMID:5124805
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1176742/
Abstract
摘要