Howell R M, Dupe R J
Br J Exp Pathol. 1971 Oct;52(5):495-502.
Digitonin in association with barium sulphate adsorbable protein solution may play more than one role in the induction of an experimental hypercoagulable state leading to intravascular coagulation. Firstly, it initiates a weak clotting stimulus presumably by complexing with cholesterol it brings about the disruption of a lipoprotein complex and the exposure of an active enzyme site. Secondly, this study also demonstrated that digitonin is able to substitute for phospholipid in the acceleration of the clotting stimulus and emphasises the role of micelle-forming substances in the hypercoagulable state.
洋地黄皂苷与硫酸钡可吸附蛋白溶液联合使用，在诱导导致血管内凝血的实验性高凝状态中可能发挥多种作用。首先，它可能通过与胆固醇结合引发微弱的凝血刺激，导致脂蛋白复合物的破坏和活性酶位点的暴露。其次，本研究还表明，洋地黄皂苷能够在加速凝血刺激方面替代磷脂，并强调了形成胶束的物质在高凝状态中的作用。
