分泌成分作为大鼠肝细胞上聚合免疫球蛋白A的受体。
Secretory component as the receptor for polymeric IgA on rat hepatocytes.
作者信息
Orlans E, Peppard J, Fry J F, Hinton R H, Mullock B M
出版信息
J Exp Med. 1979 Dec 1;150(6):1577-81. doi: 10.1084/jem.150.6.1577.
Abstract
Rat hepatocytes in short-term monolayer cultures bound radiolabeled polymeric rat IgA but not IgG. The binding of 125I-IgA was inhibited equally well by unlabeled polymeric IgA and by antiserum to rat secretory component (SC). The antibody to SC, after specific purification and radiolabeling, was bound to hepatocytes as effectively as the IgA. These results indicate that SC acts as the receptor for polymeric IgA on rat hepatocytes as it does on human gut epithelia, and that the transport of IgA from blood to bile in rats across the liver is analogous to that of IgA across human enterocytes.
摘要
短期单层培养的大鼠肝细胞能结合放射性标记的聚合大鼠IgA，但不能结合IgG。未标记的聚合IgA和抗大鼠分泌成分（SC）的抗血清对125I-IgA的结合抑制效果相同。经特异性纯化和放射性标记后的抗SC抗体与肝细胞的结合效果与IgA一样有效。这些结果表明，SC在大鼠肝细胞上作为聚合IgA的受体，其作用方式与在人肠道上皮细胞上相同，并且大鼠体内IgA从血液到胆汁经肝脏的转运类似于IgA经人肠细胞的转运。
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