胆管梗阻大鼠血清中分泌型IgA和游离分泌成分水平升高。
High levels of secretory IgA and free secretory component in the serum of rats with bile duct obstruction.
作者信息
Lemaître-Coelho I, Jackson G D, Vaerman J P
出版信息
J Exp Med. 1978 Mar 1;147(3):934-9. doi: 10.1084/jem.147.3.934.
Abstract
In the rat , ligation of the bile duct induces a rapid and progressive elevation of the IgA levels in serum. The increase is about 4-fold at 1 h, 15-fold at 1 day, and 30-fold at 1 wk after ligation. The additional IgA is of the secretory type. Free secretory component also appears in serum after bile duct obstruction; it does not continue to increase and occasionally disappears from serum after prolonged ligation. The increase in serum IgA levels is selective. These changes are totally reversible if the bile duct is reopened at 1 day after ligature. These findings confirm the role of the rat liver in the transfer of circulating IgA into the bile.
摘要
在大鼠中，结扎胆管会导致血清中IgA水平迅速且持续升高。结扎后1小时增加约4倍，1天增加15倍，1周增加30倍。额外的IgA是分泌型的。胆管阻塞后，游离分泌成分也会出现在血清中；它不会持续增加，长时间结扎后偶尔会从血清中消失。血清IgA水平的升高具有选择性。如果在结扎后1天重新开放胆管，这些变化是完全可逆的。这些发现证实了大鼠肝脏在将循环IgA转运到胆汁中的作用。
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