Mokhtar N M, Spector W G
J Pathol. 1979 Jul;128(3):117-26. doi: 10.1002/path.1711280302.
Mouse peritoneal macrophages collected after exposure to new born calf serum in vivo were found to have some of the morphological and ultrastructural features attributed to epithelioid cells. These features were accentuated by short term culture in vivo or in vitro. Three accepted varieties of epithelioid cell were reproduced, i.e., those with predominant rough ER, those with predominant smooth vesicles and the plasmacytoid variety. Cells resembling fibroblasts were not seen, nor were lymphoid cells. The facsimile epithelioid cells had considerable secretory activity for a range of macrophage enzymes. They retained the phagocytic capacity and the surface receptors of macrophages but to a reduced extent. It is suggested that epithelioid cells are a form of stimulated macrophage, especially effective in enzyme secretion and liable to appear after excitation of the cell membrane by pinocytosis rather than phagocytosis.
在体内接触新生小牛血清后收集的小鼠腹腔巨噬细胞，被发现具有一些归因于上皮样细胞的形态学和超微结构特征。这些特征在体内或体外短期培养后会更加明显。再现了三种公认的上皮样细胞类型，即主要具有粗面内质网的细胞、主要具有光滑小泡的细胞和浆细胞样细胞类型。未见到类似成纤维细胞的细胞，也未见到淋巴细胞。这些模拟上皮样细胞对一系列巨噬细胞酶具有相当大的分泌活性。它们保留了巨噬细胞的吞噬能力和表面受体，但程度有所降低。有人提出，上皮样细胞是一种受刺激的巨噬细胞形式，在酶分泌方面特别有效，并且容易在细胞膜通过胞饮作用而非吞噬作用受到刺激后出现。
