Dervan P A, Hayes J A
J Pathol. 1979 Jul;128(3):143-9. doi: 10.1002/path.1711280305.
Following exposure to an aerosol of 0.1 per cent. (0.005M) cadmium chloride in physiologic saline, rat lungs were examined at 1 hour, 1, 2, 3, 4, 5, 7, 10 and 21 days. Light microscopy showed that damage was most marked about respiratory bronchioles with a prominent increase in interstitial cells. Up to 3 days the intestitial cells were closely packed and monocytic in type, but on the fourth and fifth days, the cellular density had decreased and elongated cells resembling fibroblasts appeared. By 7 days the interstitial cells were predominantly fibroblastic. Ultrastructurally the fibroblasts were active with prominent rough endoplasmic reticulum and numerous, single, haphazardly scattered collagen fibrils in lacunae at the cell margins. At 21 days after injury, interstitial collagen was seen as well organised, mature bundles. The fibrosis was seen in a peribronchiolar position with distoration of the bronchiole and adjacent alveoli. We suggest that the peribronchiolar localisation of fibrosis is the probable cause of centriacinar emphysema resulting from acute cadmium fume poisoning in man.
将大鼠暴露于含0.1%（0.005M）氯化镉的生理盐水气雾剂中后，分别在1小时、1、2、3、4、5、7、10和21天对大鼠肺部进行检查。光学显微镜检查显示，损伤在呼吸性细支气管周围最为明显，间质细胞显著增多。在3天内，间质细胞紧密排列，呈单核细胞类型，但在第4天和第5天，细胞密度降低，出现了类似成纤维细胞的细长细胞。到第7天时，间质细胞主要为成纤维细胞。超微结构显示，成纤维细胞活跃，粗面内质网突出，细胞边缘的腔隙中有许多单个、随机散布的胶原纤维。损伤后21天，间质胶原呈现为排列有序的成熟束状。纤维化出现在细支气管周围，导致细支气管和相邻肺泡变形。我们认为，纤维化的细支气管周围定位可能是人类急性镉烟中毒导致小叶中心型肺气肿的原因。
