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Determination of time course of in vivo pharmacological effects from in vitro drug-release testing.

作者信息

Smolen V F

出版信息

J Pharm Sci. 1971 Jun;60(6):878-82. doi: 10.1002/jps.2600600615.

DOI:10.1002/jps.2600600615
PMID:5128937
Abstract
摘要

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Linear systems analysis and moment analysis in the evaluation of bacampicillin bioavailability from microcapsule suspensions.线性系统分析和矩量分析在评估微胶囊悬浮液中巴卡西林生物利用度中的应用
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Dose-effect curves and relative biophasic drug levels: elucidation of these concepts and the illustration of their use for the determination of bioavailability, rate of absorption, and time course of pharmacological response.
J Pharmacokinet Biopharm. 1976 Feb;4(1):67-80. doi: 10.1007/BF01271445.
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Theoretical and computational basis for drug bioavailability determinations using pharmacological data. II. Drug input in equilibrium to response relationships.
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