发育中大鼠脑内牛磺酸和半胱亚磺酸脱羧酶的亚细胞分布
Subcellular distribution of taurine and cysteinesulphinate decarboxylase in developing rat brain.
作者信息
Agrawal H C, Davison A N, Kaczmarek L K
出版信息
Biochem J. 1971 May;122(5):759-63. doi: 10.1042/bj1220759.
Abstract
The concentration of taurine and the activities of cysteinesulphinate decarboxylase and glutamate decarboxylase have been measured in rat brain. During development, taurine exhibited a decrease in concentration unrelated to the activity of cysteinesulphinate decarboxylase which increased during the same period. The distribution of taurine in subcellular fractions of adult and 7-day-old rat brain was typical of most amino acids, whereas half of the cysteinesulphinate decarboxylase activity was found in the nerve-ending cytoplasm. In anatomical distribution, taurine displayed great regional heterogeneity but both cysteinesulphinate decarboxylase and glutamate decarboxylase were more evenly distributed. Hypertaurinaemia was shown to have no effect on the entry of glycine into the brain or on its utilization in protein synthesis.
摘要
已对大鼠脑中的牛磺酸浓度以及半胱亚磺酸脱羧酶和谷氨酸脱羧酶的活性进行了测定。在发育过程中，牛磺酸浓度呈现下降趋势，这与同期活性增加的半胱亚磺酸脱羧酶的活性无关。牛磺酸在成年大鼠和7日龄大鼠脑亚细胞组分中的分布是大多数氨基酸的典型分布，而半胱亚磺酸脱羧酶活性的一半存在于神经末梢细胞质中。在解剖分布上，牛磺酸表现出很大的区域异质性，但半胱亚磺酸脱羧酶和谷氨酸脱羧酶分布更为均匀。高牛磺酸血症被证明对甘氨酸进入大脑或其在蛋白质合成中的利用没有影响。
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本文引用的文献
1
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Nature. 1949 Nov 26;164(4178):923. doi: 10.1038/164923a0.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
SUBCELLULAR DISTRIBUTION OF THE ENZYMES OF THE GLUTAMIC ACID, GLUTAMINE AND GAMMA-AMINOBUTYRIC ACID CYCLES IN RAT BRAIN.大鼠脑中谷氨酸、谷氨酰胺和γ-氨基丁酸循环中酶的亚细胞分布
J Neurochem. 1965 Apr;12:287-309. doi: 10.1111/j.1471-4159.1965.tb06766.x.
4
TAURINE EXCRETION AND INTELLIGENCE IN MONGOLISM.蒙古症中的牛磺酸排泄与智力
Proc Soc Exp Biol Med. 1965 Jul;119:832-3. doi: 10.3181/00379727-119-30313.
5
MICROASSAY OF BIOCHEMICAL STRUCTURAL COMPONENTS IN NERVOUS TISSUES. II. METHODS FOR CEREBROSIDES, PROTEOLIPID PROTEINS AND RESIDUE PROTEINS.神经组织中生化结构成分的微量分析。II. 脑苷脂、蛋白脂质蛋白和残留蛋白的分析方法。
J Neurochem. 1965 Mar;12:205-11. doi: 10.1111/j.1471-4159.1965.tb06756.x.
6
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J Pharmacol Exp Ther. 1964 Apr;144:110-5.
7
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9
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