Rassin D K, Sturman J A, Gaull G E
Neurochem Res. 1982 Sep;7(9):1107-18. doi: 10.1007/BF00964889.
The relationship of taurine to glutamate, and to other amino acids, has been examined in the occipital lobe of the developing rhesus monkey. During development taurine decreases in concentration (4.96 mumol/g in fetus to 1.52 mumol/g in adult) while glutamate increases (7.92 mumol/g in fetus to 11.26 mumol/g in adult). When the concentration of taurine is plotted against that of glutamate in fetal, neonatal and adult animals there is a significant correlation in the fetal (p less than 0.01) and adult (p less than 0.01) but not in the neonatal occipital lobe samples. This correlation in both fetal and adult brain is specific for these amino acids. Subcellular fractionation studies further indicate that this relationship may be of special importance in nerve endings.
已对发育中的恒河猴枕叶中牛磺酸与谷氨酸及其他氨基酸的关系进行了研究。在发育过程中，牛磺酸浓度降低（胎儿期为4.96微摩尔/克，成年期为1.52微摩尔/克），而谷氨酸浓度升高（胎儿期为7.92微摩尔/克，成年期为11.26微摩尔/克）。当绘制胎儿、新生儿和成年动物中牛磺酸浓度与谷氨酸浓度的关系图时，胎儿（p<0.01）和成年（p<0.01）枕叶样本中存在显著相关性，但新生儿枕叶样本中不存在。胎儿和成年大脑中的这种相关性对这些氨基酸具有特异性。亚细胞分级分离研究进一步表明，这种关系在神经末梢可能特别重要。
