地西泮在肝脏疾病中的临床及脑电图评估
Clinical and electroencephalographic assessment of diazepam in liver disease.
作者信息
Murray-Lyon I M, Young J, Parkes J D, Knill-Jones R P, Williams R
出版信息
Br Med J. 1971 Oct 30;4(5782):265-6. doi: 10.1136/bmj.4.5782.265.
Abstract
The effects of 5 mg of diazepam intravenously were assessed in 23 patients with liver disease, 10 of whom had clinical evidence either in the past or at the time of study of hepatic encephalopathy. Transient drowsiness occurred in all patients, but prolonged deterioration in conscious level was not observed. Serial electroencephalographic recordings showed the development of activity at faster frequencies, similar to that found in normal subjects, a change which is different from that usually observed in cirrhotic patients after administration of chlorpromazine and morphine when slow-wave activity is increased.
摘要
对23例肝病患者静脉注射5毫克地西泮的效果进行了评估，其中10例在过去或研究时具有肝性脑病的临床证据。所有患者均出现短暂嗜睡，但未观察到意识水平的持续恶化。连续脑电图记录显示出现了频率更快的活动，类似于在正常受试者中发现的情况，这种变化与肝硬化患者在使用氯丙嗪和吗啡后通常观察到的情况不同，后者慢波活动会增加。
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