地西泮在肝脏疾病中的临床及脑电图评估
Clinical and electroencephalographic assessment of diazepam in liver disease.
作者信息
Murray-Lyon I M, Young J, Parkes J D, Knill-Jones R P, Williams R
出版信息
Br Med J. 1971 Oct 30;4(5782):265-6. doi: 10.1136/bmj.4.5782.265.
Abstract
The effects of 5 mg of diazepam intravenously were assessed in 23 patients with liver disease, 10 of whom had clinical evidence either in the past or at the time of study of hepatic encephalopathy. Transient drowsiness occurred in all patients, but prolonged deterioration in conscious level was not observed. Serial electroencephalographic recordings showed the development of activity at faster frequencies, similar to that found in normal subjects, a change which is different from that usually observed in cirrhotic patients after administration of chlorpromazine and morphine when slow-wave activity is increased.
摘要
对23例肝病患者静脉注射5毫克地西泮的效果进行了评估，其中10例在过去或研究时具有肝性脑病的临床证据。所有患者均出现短暂嗜睡，但未观察到意识水平的持续恶化。连续脑电图记录显示出现了频率更快的活动，类似于在正常受试者中发现的情况，这种变化与肝硬化患者在使用氯丙嗪和吗啡后通常观察到的情况不同，后者慢波活动会增加。
相似文献
1
Clinical and electroencephalographic assessment of diazepam in liver disease.地西泮在肝脏疾病中的临床及脑电图评估
Br Med J. 1971 Oct 30;4(5782):265-6. doi: 10.1136/bmj.4.5782.265.
2
[ELECTROENCEPHALOGRAPHIC STUDIES IN CHRONIC LIVER DISEASE BEFORE AND AFTER MORPHINE ADMINISTRATION: ATTEMPT AT AN OBJECTIVATION OF THE DIAGNOSIS "PRECOMA" AND "HEPATIC COMA"].[慢性肝病患者在注射吗啡前后的脑电图研究：对“前驱昏迷”和“肝昏迷”诊断客观化的尝试]
Dtsch Med Wochenschr. 1964 Apr 10;89:748-55. doi: 10.1055/s-0028-1111083.
3
Treatment and prevention of acute hepatic encephalopathy by intravenous levodopa.
Surgery. 1974 Feb;75(2):188-91.
4
[STUDIES ON TRIPHASIC WAVE IN HEPATIC ENCEPHALOPATHY].[肝性脑病中三相波的研究]
Seishin Shinkeigaku Zasshi. 1963 Jun;65:502-13.
5
Intravenous administration of diazepam in patients with chronic liver disease.慢性肝病患者静脉注射地西泮
Gut. 1976 Dec;17(12):975-83. doi: 10.1136/gut.17.12.975.
6
Hepatic encephalomyelopathy: a complication following liver cirrhosis caused by Budd-Chiari syndrome and HBV.
J Infect Dev Ctries. 2014 Apr 15;8(4):551-3. doi: 10.3855/jidc.3052.
7
[1 (+) ornithine alpha ketoglutarate in hepatic encephalopathy].[1（+）鸟氨酸α-酮戊二酸在肝性脑病中的应用]
Presse Med (1893). 1970 Jun 20;78(30):1367-8.
8
[Corticosteroid therapy in hepatic diseases].
Recenti Prog Med. 1967 Jul;43(1):51-70.
9
Treatment of cirrhotic hepatic encephalopathy with L-dopa. A controlled trial.左旋多巴治疗肝硬化肝性脑病。一项对照试验。
Gastroenterology. 1980 Aug;79(2):207-11.
10
Clinical and electroencephalographic correlation in hepatic encephalopathy in 15 cases.15例肝性脑病的临床与脑电图相关性研究
J Assoc Physicians India. 1972 Jun;20(6):423-8.
引用本文的文献
1
Benzodiazepines and risk for hepatic encephalopathy in patients with cirrhosis and ascites.苯二氮䓬类药物与肝硬化腹水患者发生肝性脑病的风险
United European Gastroenterol J. 2018 Apr;6(3):407-412. doi: 10.1177/2050640617727179. Epub 2017 Aug 23.
2
The effects of age and liver disease on the disposition and elimination of diazepam in adult man.年龄和肝脏疾病对成年男性体内地西泮处置与消除的影响。
J Clin Invest. 1975 Feb;55(2):347-59. doi: 10.1172/JCI107938.
3
Intravenous administration of diazepam in patients with chronic liver disease.慢性肝病患者静脉注射地西泮
Gut. 1976 Dec;17(12):975-83. doi: 10.1136/gut.17.12.975.
4
Pharmacokinetics of diazepam in disordered liver function.肝功能紊乱时地西泮的药代动力学
Eur J Clin Pharmacol. 1976 Jun 15;10(2):115-20. doi: 10.1007/BF00609469.
5
Drug prescribing in hepatobiliary disease.
Drugs. 1979 Mar;17(3):198-212. doi: 10.2165/00003495-197917030-00005.
本文引用的文献
1
EXPERIENCE WITH DIAZEPAM IN AN ELECTROENCEPHALOGRAPHY LABORATORY CONTROLLED EVALUATION.
Am J Psychiatry. 1964 May;120:1114-5. doi: 10.1176/ajp.120.11.1114.
2
The E.E.G. in hepatic encephalopathy.肝性脑病中的脑电图
Clin Sci. 1963 Feb;24:109-20.
3
Drug effects on the electroencephalographic pattern, with specific consideration of diazepam.药物对脑电图模式的影响，特别考虑地西泮。
South Med J. 1962 Aug;55:832-8. doi: 10.1097/00007611-196208000-00013.
4
Morphine tolerance in hepatic cirrhosis.肝硬化中的吗啡耐受性。
Gastroenterology. 1961 Mar;40:389-96.
5
Treatment of hepatic coma by exchange blood transfusion.换血疗法治疗肝昏迷。
N Engl J Med. 1966 Mar 3;274(9):473-81. doi: 10.1056/NEJM196603032740901.
6
Metabolism of diazepam in rat, dog, and man.地西泮在大鼠、狗和人体内的代谢
J Pharmacol Exp Ther. 1965 Sep;149(3):423-35.
7
Effects of chlorpromazine in patients with hepatic disease.氯丙嗪对肝病患者的影响。
Br Med J. 1969 Aug 30;3(5669):497-9. doi: 10.1136/bmj.3.5669.497.
8
Neuropsychiatric and electro-encephalographic changes after transplantation of the liver.肝脏移植后的神经精神和脑电图变化
Q J Med. 1970 Oct;39(156):515-27.
9
Physiological responses to intravenous diazepam as a sedative for conservative dentistry.静脉注射地西泮作为保守牙科镇静剂的生理反应。
Br Med J. 1970 Jul 4;3(5713):10-3. doi: 10.1136/bmj.3.5713.10.
10
Blood level distribution patterns of diazepam and its major metabolite in man.地西泮及其主要代谢产物在人体中的血药浓度分布模式。
J Pharm Sci. 1966 Jul;55(7):692-702. doi: 10.1002/jps.2600550706.
Zotero 插件