Ogata K, Whiteside L A, Lesker P A, Reynolds F C
J Trauma. 1979 Dec;19(12):953-6. doi: 10.1097/00005373-197912000-00003.
Open joint wounds were made in immature and mature rabbit knees by surgical arthrotomy. The wounds of the right knees were packed open for 5 days and the left knee wounds were closed primarily. The biochemical studies were selected to determine the effect of our treatment regimen on changes in the metabolism of articular cartilage and synovium. Neither closed nor open treatment produced significant changes in enzyme activities measured in the articular cartilage as compared to the controls in either immature or mature rabbits. Most of the synovial enzymes were elevated in the injured joints. There were, however, no significant differences in enzyme activity between the joints treated by either open or closed methods. Our findings suggest that short-term open treatment wounds does not cause matrix degradation in the cartilage nor affect the synovium more than simple arthrotomy.
通过手术关节切开术在未成熟和成熟兔膝关节制造开放性关节伤口。右膝伤口敞开包扎5天，左膝伤口一期缝合。选择生化研究来确定我们的治疗方案对关节软骨和滑膜代谢变化的影响。与未成熟或成熟兔的对照组相比，无论是闭合治疗还是开放治疗，关节软骨中测量的酶活性均未产生显著变化。大多数滑膜酶在受伤关节中升高。然而，开放或闭合方法治疗的关节之间酶活性没有显著差异。我们的研究结果表明，短期开放性伤口处理不会导致软骨基质降解，对滑膜的影响也不会超过单纯的关节切开术。
